Curriculum Vitae

Anita M. Jansson Mathiesen

 

                   

Position:

Research Associate since 02/2004
Birth: March 1, 1951, Uppsala, Sweden
Nationality: Swedish
Languages: Swedish, English, Danish, moderate French
Phone: +45 33 27 52 87
Email: anita at crc.dk
   
   
EDUCATION: Master of Science in Chemical Engineering, 1976. The Royal Institute of Technology, Stockholm, Sweden.
   
  Doctor of Philosophy in Organic Chemistry, 1989. The University of Stockholm with Professor Per Garegg.
  "Design and Synthesis of Kdo-Derivatives as Inhibitors of Lipopolysaccharide Biosynthesis in Gram-Negative Bacteria. A new class of Antibacterial Agents."
   
   
POSITIONS HELD:  
1975-1976 Civil Engineer
  Department of Organic Chemistry, The Royal Institute of Technology, Stockholm, Sweden.
   
1976-1991 Senior Scientist,  Department of Antibacterial Chemotherapy, Research and Development Laboratories, ASTRA, AB, Södertälje, Sweden
   
1990-1991

Postdoctoral Fellow

Department of Chemistry, Carlsberg

Laboratories,Copenhagen, Denmark. (On leave

from ASTRA AB)

 
1992-

Research Associate,

Department of Chemistry, Carlsberg Laboratory, Copenhagen, Denmark
   
   
PUBLICATIONS:  
 

Trans-Perillenal, A Furanoid Monoterpene from Pine Saw-Fly, Neodiprion sertifer.

Göran Ahlgren, Gunnar Bergström, Jan Löfqvist, Anita Jansson, and Torbjörn Norin.

Journal of Chemical Ecology Vol 5, no.3 (1979) 309-319.
   
 

Labelled Compounds of Potential Biological Interest VII. Synthesis of 3-deoxy-D-Manno-[1-14C]octulosonic Acid (D-manno-KDO) of High Specific Activity.

Göran Bondesson, Ingrid Fagervall, Tamas Gosztonyi, Anita Jansson, and Annesophie Ohlberger.

Journal of Labelled Compounds & Radiopharmaceuticals Vol.XIX, No. 2 (1982) 239-246.
   
 

A New Class of Synthetic Antibacterials Acting on Lipopolysaccharide Biosynthesis.

Stephen M Hammond, Alf Claesson, Anita M Jansson, Lars-Gunnar Larsson, Brian G Pring, Christine M Town, and Bertil Ekström.

Nature Vol. 327, No 6124 (1987) 730-732.
   
 

Synthesis of Analogues of 3-deoxy-D-manno-octulosonic Acid (KDO) as Potential Inhibitors of CMP-KDO Synthetase.

Kristina Luthman, Alf Claesson, Anita M Jansson, and Brian G Pring.

Carbohydrate Research Vol. 166 (1987) 233-251.
   
 

Design and Synthesis of Peptide Derivatives of a 3-Deoxy-D-manno-2-octulosonic Acid (KDO) Analogue as Novel Antibacterial Agents Acting upon Lipopolysaccharide Biosynthesis.

Alf Claesson, Anita M Jansson, Brian G Pring, Stephen M Hammond, and Bertil Ekström.

Journal of Medicinal Chemistry Vol. 30 (1987) 2309-2313.
   
 

Synthesis of a Tritiated LPS Inhibitor Derived from 3-Deoxy-D-manno-2-octulosonic Acid (KDO). A cautionary Note Regarding Amide Synthesis from Azides via Phosphine Imines.

Christer Sahlberg, Anita M Jansson, and Alf Claesson.

Acta Chemica Scandinavica Vol. B12 (1988) 556-562.

   
 

Synthesis of 8-Substituted Derivatives of the 2-Deoxy Analogue of 3-Deoxy-β-D-manno-2-octulopyranosonic Acid (2-Deoxy-β-KDO) as Inhibitors of 3-Deoxy-D-manno-octulosonate Cytidyltransferase.

Brian G Pring, Anita M Jansson, Kerstin Persson, Inger Andersson, Ingalill Gagner-Milchert, Kent Gustafsson, and Alf Claesson.

Journal of Medicinal Chemistry Vol. 32 (1989) 1069-1074.

   
 

Design and Synthesis of KDO-Derivatives as Inhibitors of Lipopolysaccharide Biosynthesis in Gram-Negative Bacteria. A New Class of Antibacterial Agents.

Anita M Jansson.

Doctoral Dissertation 1989, Department of Organic Chemistry, University of Stockholm.

Chemical Communications, University of Stockholm No.5 (1989).
   
 

The Active Ester N-Fmoc-3-O-[Ac4-α-D-Manp-(1-2)-Ac3-α-D-Manp-1-]-Threonine-OPfp as a Building Block in Solid-Phase Synthesis of an O-Linked Dimannosyl Glycopeptide.

Anita M Jansson, Morten Meldal, and Klaus Bock.

Tetrahedron Letters Vol. 31 No 48 (1990) 6991-6994.
   
 

Solid-Phase Synthesis and Characterization of O-Dimannosylated Heptadecapeptide Analogues of Human Insulin-Like Growth Factor 1 (IGF-1).

Anita M Jansson, Morten Meldal, and Klaus Bock.

J.Chem.Soc.Perkin.Trans.1 (1992) 1699-1707.
   
 

Active Esters in Solid Phase Glycopeptide Synthesis: A General Approach.

Morten Meldal, Knud J.Jensen, Anita M Jansson,and Klaus Bock.

In Innovation and Perspectives in Solid Phase Synthesis. Edited by R.Epton.Intercept:

Andover, UK   (1992)  179-184.
   
 

N-Fmoc-8-Amino-2,8-Dideoxy-β-Kdo Pentafluorophenyl Ester Used as a Building Block in Multiple Column Solid Phase Neoglycopeptide Synthesis.

Anita M Jansson, Morten Meldal, and Klaus Bock.

In Innovation and Perspectives in Solid Phase Synthesis. Edited by R. Epton. Mayflower Worldwide Ltd: Birmingham (1994) 559-562.
   
 

Silyl Protection in the Solid-Phase Synthesis of N-Linked Glycopeptides. Preparation of Glycosylated Fluorogenic Substrates for Subtilisins.

Ida Christiansen-Brams, Anita M. Jansson, Morten Meldal, Klaus Breddam, and Klaus Bock.

Bioorganic & Medicinal Chemistry (1994) 1153-1167
   
 

Solid-Phase Glycopeptide Synthesis of Tyrosine-Glycosylated Glycogenin Fragments as Substrates for Glucosylation by Glycogenin.

Anita M. Jansson, Knud J. Jensen, Morten Meldal, Joseph Lomako, Wieslawa M. Lomako, Carl Erik Olsen, and Klaus Bock.

J.Chem.Soc.Perkin.Trans.1 (1996) 1001-1006.
   
 

Spectroscopic and Protein Chemical Analyses Demonstrate the Presence of C-Mannosylated Tryptophane in Intact Human RNase 2 and its Isoforms.

Andreas Löffler, Marie-Agnès Doucey, Anita M. Jansson, Dieter R. Müller, Tonny de Beer, Daniel Hess, Morten Meldal, Wilhelm J. Richter, Johannes F.G Vligenthart, and Jan Hofsteenge.

Biochemistry (1996) 12005-12014.
   
 

Azido Acids in a Novel Method of Solid-Phase Peptide Synthesis.

Morten Meldal, Maria A. Juliano, and Anita M. Jansson.

Tetrahedron Letters (1997) 2531-2534.
   
 

Novel PEG-Based Resins and Synthetic Methods: Azido Acids in SPPS and Direct Solid Phase Peptide Glycosylations.

Morten Meldal, Manat Renil, Maria A. Juliano, Anita M. Jansson, Ernst Meinjohanns, Jens Buchardt, and Axel Schleyer.

In Peptides 1996. Edited by R. Ramage and R. Epton. Mayflower Scientific Ldt: Kingswinford, UK, (1998) 141-152.
   
 

Azido Acids in a Novel Method of Solid Phase Synthesis.

Morten Meldal, Christian Tornoe, Ulf Tedebark, Anita M. Jansson, Maria A.

Juliano, Luigi Panza, and Luigi Layn.

Innovation and Perspectives inSolid Phase Synthesis.  Edited by R Epton. Mayflower Ltd:

Scientific Birmingham, UK (1999) 19-22
   
 

Azido Acids in a Novel Method of Automated Solid-Phase Synthesis.

Anita M. Jansson and Morten Meldal.

In Peptides 1998. Edited by S. Bajusz and F. Hudecz. Akadémiai Kiadó: Budapest (1999) 94-95.
   
 

Synthesis and Applications of Sialic Acid-Containing Building Blocks for Glycopeptide Libraries. Establishing Glycosylation Conditions.

Koen M. Halkes, Phaedria M. St Hilaire, Anita M. Jansson,

Charlotte H.Gotfredsen, and Morten Meldal.

J. Chem Soc., Perkin Trans 1 (2000) 2127-2133.
   
 

Palladium on Carbon Encapsulated in POEPOP1500: A Resin-Supported Catalyst for Hydrogenation Reactions.

Anita M. Jansson, Morten Grötli, Koen M. Halkes, and Morten Meldal.

Organic Letters (2002) 27-30.
   
 

Synthesis of Glycopeptides.

Anita M. Jansson, Phaedria M. St. Hilaire, and Morten Meldal

In Houben-Weyl, Vol E22b: Synthesis of Peptides and Peptidomimetics Edited by M. Goodman. Thieme: Stuttgart (2003) 235-332
   
 

Patent: New Antibacterial Agents and Intermediates.

Alf Claesson, Stephen M Hammond, Anita M Jansson, and Brian G.Pring.

European Patent Application No 86850438.2 (1986).