Curriculum Vitae

Mads Detlef Sørensen

Name: Mads Detlef Sørensen

Position: Post-Doctoral Fellow since 12/2003

Birth: August 3, 1972, Gentofte, Denmark

Nationality: Danish

Languages: Danish, English, German

Phone: +45 33 27 53 13

E-mail: mds at crc.dk   

Education

Sep. 1992 – Master studies in Science, Chemistry and Business Economics, University of Odense, Denmark.

Including:

- Bachelor’s degree in Chemistry. Project title: "Synthesis of Acylated 2-deoxy-D-ribofuranose derivatives". Supervisor: Jesper Wengel.

- Master’s degree in Chemistry. Thesis title: "Synthesis of 1'-Aza-C-nucleosides. A New Type of Nucleosides". Supervisor: Erik Bjerregaard Pedersen.

Mar. 2000 – Ph.D. studies in Chemistry, Department of Chemistry, University of Copenhagen, Denmark.

Including:

- Visiting Ph.D. student at Medical Research Council, Laboratory of Molecular Biology, Cambridge, England, with Dr. Mike Gait (Oct. 2001 to Mar. 2002).

- Ph.D. degree in Chemistry. Project title: "Synthesis and evaluation of LNA analogues: a-L-LNA and 2’-amino-LNA". Supervisors: Jesper Wengel and Otto Dahl.

Working Experience

1998 Teacher in "Laboratory course in organic chemistry", University of Odense, Denmark.

May 1999 – Research assistant in The DNA Chemistry Group, Department of Chemistry, University of Copenhagen, Denmark.

2001 Teacher in "Organic Chemistry (KemiG-O)", University of Copenhagen, Denmark.

Oct 2003 – Research assistant at the Nucleic Acid Centre, Department of Chemistry, University of Southern Denmark, Odense, Denmark.

Dec 2003 – Post Doctoral position at Carlsberg Research Laboratory, Valby, Denmark

Publications

  1. Prasad, A. K., Sørensen, M. D., Parmar, V. S., and Wengel, J.

    2. "Tri-O-acyl 2-Deoxy-D-ribofuranose: An effective Enzyme-assisted One-pot Synthesis from 2-Deoxy-D-ribose and Transformation into 2'-Deoxynucleosides".

    Tetrahedron Letters, 1995, 36, 6163.

     

  2. Sørensen, M. D., Khalifa, N. M., and Pedersen, E. B.

    3. "Aza-C-nucleosides as a New Class of Nucleosides".

    Synthesis, 1999, 11, 1937.

     

  3. Rajwanshi, V. K., Håkansson, A. E., Sørensen, M. D., Pitsch, S., Singh, S. K., Kumar, R., Nielsen, P., and J. Wengel.

    4. "The Eight Stereoisomers of LNA (Locked Nucleic Acid): A Remarkable Family of Strong RNA Binding Molecules".

    Angewandte Chemie, International Edition, 2000, 39, 1656.

     

  4. Håkansson, A. E., Koshkin, A. A., Sørensen, M. D., and Wengel, J.

    5. "Convenient Syntheses of 7-Hydroxy-1-hydroxymethyl-3-(thymin-1-yl)-2,5-dioxabicyclo[2.2.1]heptanes: a -L-ribo- and a -L-xylo-configured LNA Nucleosides".

    Journal of Organic Chemistry, 2000, 65, 5161.

     

  5. Sørensen, M. D., Meldgaard, M., Rajwanshi, V. K., and Wengel, J.

    6. "Y-Shaped Branched Oligonucleotides Containing Bicyclic Nucleotides as Branching Points and DNA or LNA as Triplex Forming Branch".

    Bioorganic Medicinal Chemistry Letters, 2000, 10, 1853.

    Sørensen, M. D., Meldgaard, M., Raunkjær, M., Rajwanshi, V. K., and Wengel, J.

    Corrigendum, Bioorganic Medicinal Chemistry Letters, 2001, 11, 751.

     

  6. Wengel, J., Petersen, M., Nielsen, K. E., Jensen, G. A., Håkansson, A. E., Kumar, R., Sørensen, M. D., Rajwanshi, V. K., Bryld, T., and Jacobsen, J. P.

    7. "LNA (Locked Nucleic Acid) and the Diastereoisomeric a-L-LNA: Conformational
    Tuning and High-affinity Recognition of DNA/RNA Targets".

    Nucleosides Nucleotides and Nucleic Acids, 2001, 20, 389.

     

  7. Sørensen, M. D., Kværnø, L., Bryld, T., Håkansson, A. E., Keinicke, L., Verbeure, B., Herdewijn, P., and Wengel, J.

    8. "The a-L-ribo-isomers of RNA and LNA (locked nucleic acid)".

    Nucl. Acids Res. Suppl. 1, 2001, 25-6. Proceedings of the 28th Symposium on Nucleic Acids Chemistry, Yokohama, 2001.

     

  8. Vester, B., Lundberg, L. B., Sørensen, M. D., Babu, R. B., Douthwaite, S., and Wengel, J.

    9. "LNAzymes: Incorporation of LNA-Type Monomers into DNAzymes Markedly Increases RNA Cleavage)".

    Journal of the American Chemical Society, 2002, 124, 13683.

     

  9. Sørensen, M. D., Kværnø, L., Bryld, T., Håkansson, A. E., Verbeure, B., Gaubert, G., Herdewijn, P., and Wengel, J.
    "    a-L-ribo-Configured Locked Nucleic Acids (a-L-LNA)".

    10. Journal of the American Chemical Soceity, 2002, 124(10), 2164.

     

  10. Keinicke, L., Sørensen, M. D., and Wengel, J.

    11. "a-L-RNA (a-L-ribo Configured RNA): Synthesis and RNA-Selective Hybridization of a-L-RNA/a-L-LNA Chimera".

    Bioorganic Medicinal Chemistry Letters, 2002, 12(4), 593.

     

  11. Rosenbohm, C., Christensen, S. M., Sørensen, M. D., Sejer Pedersen, D., Larsen, L.-E., Wengel, J., and Koch, T.
    "Synthesis of 2’-Amino-LNA: a New Strategy".

    12. Organic and Biomolecular Chemistry, 2003, 1, 655.

     

  12. Poopeiko, N. E., Juhl, M., Vester, B., Sørensen, M. D., Wengel, J.
    "Xylo-Configured Oligonucleotides (XNA, Xylo Nucleic Acid): Synthesis of Conformationally Restricted Derivatives and Hybridization towards DNA and RNA Complements".

    13. Bioorganic Medicinal Chemistry Letters, 2003, 13(14), 2285.

     

  13. Sørensen, M. D., Petersen, M., Wengel, J.
    "Functionalized LNA (Locked Nucleic Acid): High-Affinity Hybridization of Oligonucleotides Containing N-Acylated and N-alkylaed 2’-amino-LNA monomers".

    14. Chemical Communications, 2003, 17, 2130.

     

  14. Sørensen, M. D., Wengel, J., Koch, T., Christensen, S. M., Rosenbohm, C., Pedersen, D. S.
    "Synthesis of Locked Nucleic Acid Derivatives".

    15. PCT International Publication Number WO 03/095467 (2003).

     

  15. Arzumanov, A., Stetsenko, D.A., Malakhov, A.D., Reichelt, S., Sørensen, M.D., Babu, B.R., Wengel, J., Gait, M.J.

    16. "A structure-activity study of the inhibition of HIV-1 Tat-dependent trans-activation by mixmer 2’-O-methyl oligoribonucleotides containing locked nucleic acid (LNA), a-L-LNA or 2’-thio-LNA residues"

    Oligonucleotides, 2003, 13, 435.

     

  16. Raunak, Babu, B. R., Sørensen, M. D., Parmar, V. S., Harrit, N. H., Wengel, J.
    "Oligodeoxynucleotides containing     a-L-ribo configured LNA-type C-aryl nucleotides".

    Org. Biomol. Chem., 2004, 2, 80.

     

  17. Christensen, N. K., Bryld, T., Sørensen, M. D., Arar, K., Wengel, J., Nielsen, P.

    "Parallel nucleic acid recognition by the LNA (locked nucleic acid) stereoisomers b-L-LNA and a-D-LNA; studies in the mirror image world".

    Chemical Communications, 2004, 3, 282.

     

  18. Vester, B., Lundberg, L.B., Sørensen, M.D., Babu, B.R., Douthwaite, S., Wengel, J.

    "Improved RNA cleavage by LNAzyme derivatives of DNAzymes".

    Biochemical Society Transactions, 2004, Vol. 32, part 1, 37. Nucleic Acids Chemistry and Biology: The 5th Cambridge Symposium.

     

  19. Sun, B.-W., Babu, B. R., Sørensen, M. D., Zakrzewska, K., Wengel, J., C., Sun, J.-S.

    "Sequence and pH effects of LNA-containing triple helix-forming oligonucleotides: Physical chemistry, biochemistry, and modeling studies".

    Biochemistry, 2004, 43, 4160.

     

  20. Crinelli, R., Bianchi, M., Gentilini, L., Palma, L., Sørensen, M. D., Bryld, T., Babu, B. R., Arar, K., Wengel, J., Magnani, M.

    "Transcription factor decoy oligonucleotides modified with locked nucleic acids: an in vitro study to reconcile biostability with binding affinity".

    Nucleic Acids Research, 2004, 32, 1874. 

     

  21. Jepsen, J. S., Sørensen, M. D., Wengel, J. "Locked Nucleic Acid: A Potent Nucleic Acid Analog in Therapeutics and Biotechnology".

    Oligonucleotides, 2004, 14, 130-146.

  22. 22. Hrdlicka, P. J., Babu, B. R., Sørensen, M. D., Wengel, J.

    "Interstrand communication between 2'-N-(pyren-1-yl)methyl-2'-amino-LNA monomers in nucleic acid duplexes: directional control and signalling of full complementarity". Chem. Commun., 2004, 1478-79.

     

  23. Raunkjaer, M.; Sørensen, M. D., and Wengel, J."Synthesis and thermal denaturation studies of novel 2’-O,3’-C-linked bicyclic oligonucleotides with a methoxy or a piperazino group facing the major groove of nucleic acid duplexes". Organic and Biomolecular Chemistry, 2005, 3, 130-135