Malene Ryborg Jørgensen

Position: Post-Doctoral Fellow since 05/2004

Birth: December 10th, 1971,Vejle, Denmark

Nationality: Danish

Languages: Danish, English

Phone: +45 33 27 53 13

Email: mrj at crc.dk   

April 2001 – May 2004 Ph.D. student, Natural Product group, Supervisors: Associate Professor Henrik Franzyk and Professor Jerzy W. Jaroszewski, Department of Medicinal Chemistry, The Danish University of Pharmaceutical Sciences.
Solution- and Solid-phase Synthesis of Philanthotoxin Analogues: Antagonists of Ionotropic Receptors

July 2003 – November 2003 Other research experience in Professor Istvan Toth’s group, The University of Queensland, Brisbane, Australia. SPPS of Lipid Core peptide systems used as Adjuvant Carrier Systems

August 2002 – September 2002 Other research experience in Professor Peter N. R. Usherwood’s group. University of Nottingham, Nottingham, UK. Electrophysiological assays on AMPAR and nAChR.

October 2000 – April 2001 Research Assistant in Professor Robert Madsen’s group, Department of Organic Chemistry, The Technical University of Denmark.

November 1999 – August 2000 Research Assistant in Professor Geert-Jan Boons group at The Complex Carbohydrate Research Centre, University of Georgia, Athens, Georgia, USA
Solution- and Solid-Phase Synthesis of MDP Analogues

September 1998 – August 1999 Master thesis in Professor Robert Madsen’s group, Department of Organic Chemistry, The Technical University of Denmark. Synthesis of Pectin Fragments

August 1993 – August 1999 M.Sc in Chemical Engineering, Technical University of Denmark

Solid-Phase Synthesis of Elongated Philanthotoxins: Comparison of On-Resin Carboxyl Activation Methods

Malene R. Jørgensen, Matthias Witt, Jerzy W. Jaroszewski, and Henrik Franzyk,

Philanthotoxins: The Effects of Conformational Constraint and Steric Bulk in the Amino Acid Moiety on AMPAR Antagonism

Submitted to J.Med.Chem, 2004

Malene R. Jørgensen, Christian Adam Olsen, Ian R. Mellor, Peter N. R. Usherwood, Matthias Witt, Henrik Franzyk, and Jerzy W. Jaroszewski

The Choice of Phosphane in Fukuyama – Mitsunobu Alkylation: Intramolecular Selectivity between Primary and Secondary Alcohols in the Preparation of Asymmetric Tetraamine Building Blocks for Synthesis of Philanthotoxin

Eur. J. Chem., 2003, 3288-3299

Christian A. Olsen, Malene R. Jørgensen, Matthias Witt, Ian R. Mellor, Peter N. R. Usherwood, Jerzy W. Jaroszewski, and Henrik Franzyk

Regioselective Conversion of Primary Alcohols into Iodides in Unprotected Methyl Furanosides and Pyranosides.

Synthesis, 2002, 1721-1727

Philip R. Skaanderup, Carina Storm Poulsen, Lene Hyldtoft, Malene R. Jørgensen, and Robert Madsen

Synthesis and Proinflammatory Effects of Peptidoglycan-Derived Neoglycopeptide Polymers.

J. Am. Chem. Soc. 2001, 123, 8145-8146

Aloysius Siriwardena, Malene R. Jørgensen, Margreet A. Wolfert, Michael L. Vandenplas, James N. Moore, and Geert-Jan Boons

A Strategy for chemical synthesis of selectively methyl-esterified oligomers of galacturonic acid.

J. Chem. Soc., Perkin Trans.1, 2001, 543-551

Mads H. Clausen, Malene R. Jørgensen, Jesper Thorsen, and Robert Madsen