THE SECOND EUROPEAN SYMPOSIUM ON
COMBINATORIAL SCIENCES
Program for EUROCOMBI-2
June 29th –July 3rd,
Bella Center, Copenhagen, Denmark
Organised by the European Society of
Combinatorial Sciences (ESCS)
Monday, June 30 |
Opening Remarks Chair: Morten Meldal |
08:45: By the Chairman 08:50: Bodil Norild, The Danish National Research Foundation 08:55: Ferenc Darvas, Secretary of ESCS |
Supports and Solid Phase Chemistry Chair: Morten Meldal |
09:00
– IN1: Mark
Bradley, University of Southampton " |
09:25
- O1:
Andreas Marzinzik, Novartis
Pharma AG "Combinatorial
Chemistry on Macrobeads: Single Compounds from Individual Carriers" |
09:45
– O2:
Roice Michael, Carlsberg
Biosector "Synthesis
and characterization of ULTRAMINE: a high capacity polyethylenamine-based polymer and its
application as a scavenger resin" |
10:05
- O3:
Jörg Rademann “Reagent linkers for diversity-oriented preparation of compound libraries” |
10:25: Coffee Break |
Supports and Solid Phase Chemistry Chair: Mark Bradley |
10:55
– O4: Morten Meldal, Carlsberg Laboratory,
SPOCC Centre "Single
bead structure analysis, progress in MAS NMR spectroscopy and MS/MS fragmentation analysis
by ES-mass spectrometry." |
11:15
– O5:
Jamart-Gregoire Brigitte,
ENSIC-INPL "Solid
phase synthesis of chiral a
-hydrazinoacids" |
11:35
– O6:
Knud Jensen, Dept. of
Chemistry, KVL "A
highly Acid-Labile Thiophene Backbone Amide Linker: T-BAL" |
11:55: Lunch/Poster/Exhibition |
Combinatorial Synthesis and Technology Chair: Mats Larhed |
13:25
– IN2: Oliver
Kappe, Karl-Franzens University "Rapid
generation and scaffold decoration of dihydropyrimidine libraries" |
13:50
– O7:
Árpád Furka, Eötvös
Loránd University "Application
of string synthesis for preparation of cherry-picked combinatorial libraries" |
14:10
– O8:
Jin Ku Cho, University of
Southampton "Sensor
Beads and in situ Reaction Monitoring" |
14:30
– O9:
Pino Pilotti, Personal
Chemistry AB, "Solid
phase synthesis of aminopropenones and aminopropenoates as efficient and versatile
synthons for combinatorial synthesis of heterocycles" |
14:50: Break |
Combinatorial
Synthesis and Chair: Rob Liskamp |
15:20
– IN3: Günther
Jung, University of Tübingen "Combinatorial Microelectrochemistry and Fast Capillary Chromatography on Monolithic Silica Coupled to ESI-FTICR-MS" |
15:45
– O10:
A. Ganesan, University of
Southampton "New
vistas in the Pictet-Spengler reaction" |
16:05
– O11:
Thomas E. Nielsen, Carlsberg
Laboratory, SPOCC Centre "Novel
Applications of the Picket-Spengler to Solid-Phase Combinatorial Chemistry" |
16:25
– O12:
Fernando Albericio,
University of Barcelona "Solid-phase
and solution strategies for the preparation of a -Amido
Ketone-based libraries" |
16:45: Break |
Combinatorial
Synthesis and Chair: Günther Jung |
17:05
– IN4: Rob Liskamp, Utrecht University
|
17:30
– O13:
Chaim Gilon, The Hebrew
University, Jerusalem "Discovery
of SEB superantigen antagonists using backbone cyclic peptide libraries" |
17:50
– O14:
Koichi Fukase, University of
Osaka "Synthesis
based on affinity separation : rapid synthesis using affinity tag" |
Tuesday, June 31 |
Nanoscale
Synthesis, Assays Chair: Lars Baltzer |
09:00
– IN5: Manfred Auer, Novartis, Austria “CONA-HTS
(Confocal Nanoscanning - Bead-Picking - AIDA-Technology),Redefining the lead discovery
process by a joint combinatorial chemistry-, confocal fluorescence- and dye chemistry
approach” |
09:25
– O15:
György Dormán, ComGenex,
Inc. "Immobilized
surrogate compound libraries for rapid affinity profiling" |
09:45
– O16:
Ronald Frank, GBF, Germany "Highly
parallel micro-scale synthesis of structurally diverse compound repertoires: chemical
recombination of natural product fragments" |
10:05
– IN6: Ferenc
Darvas, ComGenex, Inc. "Combinatorial
Chemistry: Facing the Challenge of Micro- and Nanochemistry" |
10:30: Coffee Break |
New Scaffolds
and Natural Chair: Dennis Hall |
11:00
– IN7: Ole
Hindsgaul, University of Alberta "Screening
of Mixtures Using Frontal Affinity Chromatography Coupled to Mass Spectrometry (FAC/MS):
Emphasis on Oligosaccharide Ligands" |
11:25
– O17:
Mercedes Alvarez, University
of Barcelona "Solid
Phase Synthesis of Lamellarins" |
11:45
– O18:
Takayuki Doi, Tokyo Inst. Of
Technology "A
library synthesis of cyclic depsipeptides Aurilide and its derivatives on
solid-support" |
12:05: Lunch/Poster/Exhibition |
Combinatorial
Biochemistry Chair: Arpad Furka |
13:35
– PL1: Jim Wells,
Sunesis Pharmaceuticals, Inc. "Drug
Discovery at Signaling Interfaces" |
14:15 – O19: Phaedria St.Hilaire, Carlsberg Biosector |
14:35
– O20:
Lars Baltzer, University of
Linköbing "The
combinatorial approach to receptors, screens and sensors in designed folded polypeptides
that catalyze their own functionalization site-selectively" |
14:55
– O21:
Michael Pirrung, Duke
University "Analysis
of combinatorial mRNA splicing using Arrayed Primer Extension (APEX)" |
15:15
– IN8: Renata
Pasqualini "Mapping
Vascular Diversity by Screening Peptide Libraries"
|
15:45: Break |
16:10 –
19:00 Posters |
Wednesday, July 2 |
Drug Discovery
and Lead Chair: Steve Maginn |
09:00
– IN9: Hossain Saneii, President & CEO, Advanced SynTech "Ugi-Type
Multi-Component Condensation Reactions on Solid Support" |
09:25
– O22:
Hans Emtenas, Umea
University "Design
and Synthesis of 2-Pyridiones; Inhibition of Pili Assembly in Pathogenic Bacteria" |
09:45
– O23:
László Ürge, ComGenex,
Inc. "Novel
method for calculating the absolute diversity index (ADI) for drug candidate
libraries" |
10:05
– O24:
Lieven Meerpoel, Johnson
& Johnson Pharmaceutical Research and Development "Design,
parallel Synthesis, and Structure-Activity Relationship of Novel Microsomal Triglyceride
Transfer Protein Inhibitors" |
10:25: Coffee Break |
Drug Discovery
and Lead Chair: Ferenc Darvas |
10:55
– IN10: Takashi
Takahashi, Tokyo Institute of Technology "Solution-
and solid-phase synthesis for a library of oligosaccharides" |
11:20
– O25:
Mats Larhed, "High-Speed
Optimization of Malarial Plasmepsin I and II Inhibitors" |
11:40
– O26:
Rubén Ventura, University
of Barcelona "Functionally
diverse purine libraries as Chemical Inductors of dimerization (CID) |
12:25: Lunch/Poster/Exhibition |
Material Science and Catalysts Chair: Hubert Gstach |
13:55
– PL2: Manfred
Baerns, "Combinatorial heterogeneous catalysis - design of experiments and data analysis" |
14:35
– O27:
Helma Wennemers, University
of Basel "A
New Method for the Discovery of Catalysts in Split-and-mix Libraries" |
14:55
– O28:
Stephen Boppart, Symyx
Technologies AG "High
Throughput Exploration of the Physical and Chemical Properties of Materials and Drug
Candidates" |
15:15: Break |
Material
Science and Catalysts Chair: Manfred Baerns |
15:45
– O29: Johannes G. de Vries, DSM
Research, Life Sciences - Advanced Synthesis & Catalysis "Use of High Throughput Experimentation in Homogeneous Catalysis for Fine Chemicals" |
16:05
– O30:
Yasuhiro Uozumi, Institute
for Molecular Science, Okazaki “Development
of Amphiphilic Polymer-Supported Palladium-Phosphine Complexes: Catalysts for Green, Safe
and High-Throughput Processes” |
16:25 – O31: Eicke Kunst, University of Hanover "Pd-Catalysed
transfer hydrogenations and C-C cross coupling reactions in flowthrough reactors" |
17:15 – 1900 Posters |
|
19:15: Galla Dinner |
Thursday July 3 |
Dynamic
Libraries and Molecular Chair: Fernando Albericio |
09:00
– PL3: Jeremy
Sanders, University Chemical
Laboratory, Cambridge "Dynamic
combinatorial chemistry: New opportunities for molecular recognition and catalysis" |
09:40
– O32:
Christina Chamorro, Utrecht
University "Combinatorial
Synthesis and Screening of a CTV-based Tripodal Artificial Receptor Library" |
10:00
– O33:
Thomas Hoeg-Jensen, Novo
Nordisk A/S "Preparation
and screening of diboronate libraries for identification of new carbohydrate sensors" |
10:20
– O34:
Juan M. Benito, Carlsberg
Laboratory, SPOCC Centre "Design
and Synthesis of Cyclic Peptides as Small Molecule Receptors: A Solid-Phase Combinatorial
Approach" |
10:40: Coffee Break |
Multicomponent
Reactions in Chair: Jean Martinez |
11:10
– IN11: Alexander
Dömling, Morphochem "Three
themes in drug discovery using multicomponent reaction chemistry" |
11:35
– O35:
Andras Lukács, ComGenex,
Inc. "Novel
applications of Biginelli reaction. Solution phase parallel synthesis of
dihydropyrimidinone, dihydropyrimidinthione, dihydropyrimidothiazine libraries" |
11:55
– O36:
Dennis Hall, University of
Alberta "A
three-component reaction for the diversity-oriented combinatorial synthesis of
polysubstituted piperidines" |
12:15
– O37:
Gerardo Byk, Bar Ilan University "Anomalous
regioselective MCR4 Biginelli reaction: One pot synthesis of spiro heterobicyclic
aliphatic rings" |
12:35: Lunch/Poster/Exhibition |
Multicomponent
Reactions in Chair: Jörg Rademann |
14:05
– O38:
Jefferson Revell, University of Southampton "Polymer
Bound 9-Borabicyclo[3.3.1]nonane: A Novel and Selective Hydroborating Reagent" |
14:25
– O39:
Michael Barth, University of Tübingen "High
loaded ULTRA-resins: An evaluation of different supports and their application in
polymer-supported chemistry" |
14:45
– O40:
Birgitte Gundersen, Acadia Pharmaceuticals A/S "A
Combinatorial Scaffold Approach Based Upon a Multicomponent Reaction" |
15:05: Break |
|
15:30: Awards
and Closing Ceremony |
|
IN = Invited Lecture |
PL = Plenary Lecture |