Morten Meldal PUBLICATIONS AND PATENTS 1. Diness,F. and Meldal,M., Imidazolones in diastereoselective cyclization reactions and Cu(II)-catalysed cross-coupling reactions, Chem. Eur. J., 15 (2009) 7044-7047. 2. Jensen,J.F., Worm-Leonhard,K., and Meldal,M., Optically active (peptido-carbene) palladium complexes: towards true combinatorial solid phase libraries of transition metal catalysts, Eur. J. Org. Chem., 2008 (2008) 3785-3797 3. Worm-Leonhard,K. and Meldal,M., Green catalysts: Solid-phase peptide carbene ligands in aqueous transition metal catalysis, Eur. J. Org. Chem., 2008 (2008) 5244-5253 4. Lanfranco,M.F., Loayza-Muro,R., Clark,D., Núñez,R., Zavaleta,A.I., Jimenez,M., Meldal,M., Coombs,G.H., Mottram,J.C., Izidoro,M., Juliano,M.A., Juliano,L., and Arévalo,J. Expression and subsite specificity of a recombinant cysteine proteinase B of Leishmania braziliensis. Mol.Biochem.Parasitol. 161, 91-100. 2008. 5. Meldal,M. and Tornøe,C.W., Cu-Catalyzed Azide-Alkyne Cycloaddition, Chem. Rev., 108 (2008) 2952-3015. 6. Le Quement,S., Nielsen,T.E., and Meldal,M., Solid-Phase Synthesis of Aryl-Substituted Thienoindolizines: Sequential Pictet-Spengler, Bromination and Suzuki Cross-Coupling Reactions of Thiophenes., J. Comb. Chem., 10 (2008) 447-455. 7. Meldal,M., Polymer "clicking" by CuAAC reactions, Macromolecular Rapid Communications, 29 (2008) 1016-1051. 8. Alves,F.M., Hirata,I.Y., Gouvea,I.E., Alves,M.F.M., Meldal,M., Juliano,L. , and Juliano,M. Controlled Peptide Solvation in Portion-Mixing Libraries of FRET Peptides: Improved Specificity Determination for Dengue 2 Virus NS2B-NS3 Protease and Human Cathepsin S. J.Comb.Chem. 9, 627-634. 2007. 9. Christensen,C.A. and Meldal,M., Solid-phase synthesis of a P,S-ligand system designed for generation of combinatorial peptide-based catalyst libraries, J. Comb. Chem., 9 (2007) 79-85. 10. Le Quement,S., Nielsen,T.E., and Meldal,M. Divergent pathway for the solid phase conversion of aromatic acetylenes to carboxylic acids, -ketocarboxylic acids and methyl ketones. Journal of Combinatorial Chemistry 10, 546-556. 2008. 11. Le Quement,S., Nielsen,T.E., and Meldal,M. Scaffold diversity through intramolecular cascade reactions of solid-supported cyclic N-acyliminium intermediates. Journal of Combinatorial Chemistry 9, 1060-1072. 2007. 12. Reenberg,T., Duus,J.Ø., van Dongen,J.L.J., and Meldal,M. Specific Recognition of Disaccharides in Water by an Artificial Bicyclic Carbohydrate Receptor. European Journal of Organic Chemistry 2007, 5003-5009. 2007. 13. Nielsen,T.E., Le Quement,S., and Meldal,M. Solid-Phase Synthesis of Carboxylic and Oxamic Acids via OsO4/NaIO4/HMTA-Mediated Oxidative Cleavage of Acetylenic Peptides. Org.Lett. 9, 2469-2472. 2007. 10. Diness,F., Beyer,J., and Meldal,M., Solid-phase synthesis of tetrahydro--carbolines and tetrahydroisoquinolines by stereoselective intramolecular N-carbamyliminium Pictet-Spengler Reactions, Chem. Eur. J., 12 (2006) 8056-8066. 11. Meldal,M., Chemoffice Ultra 2006 - The ultimate software for chemists, Chembionews. com, 16.2 (2006). 14. St.Hilaire,P.M. and Meldal,M. Screening for affinity ligands for biopurification. BTI [Oct], 12-16. 2006. 15. Campos,S.V., Hilaire,P.M., Damgaard,D., and Meldal,M., GAG mimetic libraries: sulphated peptide as heparin-like glycosaminoglycan mimics in their interaction with FGF-1, QCS, 24 (2005) 923-942. 16. Christensen,S.F. and Meldal,M., Affinity ligand development in six weeks, Genetic Engineering News, 25 (2005). 17. Meldal,M., Kunstige enzymer og receptorer kan skræddersyes med kombinatorisk kemi, Carlsbergfondets Årsskrift 2005, (2005) 80-87. 18. Meldal,M. Smart assays in combinatorial chemistry. QCS 24, 1125-1126. 2005. 19. Meldal,M. Smart combinatorial assays for the determination of protease activity and inhibition. QCS 24, 1141-1148. 2005. 20. Meldal,M. Artificial Enzymes. Angew.Chem.Int.Ed. 44, 7829-7830. 2005. Wiley-VCH. 21. Minkwitz,R. and Meldal,M., Application of a Photolabile Backbone Amide Linker for cleavage of Internal Amides in the Synthesis towards Melanocortin Subtype-4 agonists, QCS, 24 (2005) 343-353. 22. Nielsen,T.E. and Meldal,M., Highly Efficient Solid-Phase Oxidative Cleavage of Olefins by OsO4-NaIO4 in the Intramolecular N-Acyliminium Pictet-Spengler Reaction , Org. Lett., 7 (2005) 2695-2698. 23. Nielsen,T.E. and Meldal,M., Solid-phase synthesis of pyrroioisoquinolines via the intremolecular N-acyliminium Pictet-Spengler reaction, J. Comb. Chem, 7 (2005) 599-610. 24. Nielsen,T.E., Le Quement,S., and Meldal,M., Solid-phase synthesis of biarylalnines via the Suzuki cross-coupling reaction and application in the intramolecular N-acyliminum Pictet-Spengler reaction, Tetrahedron Lett., 46 (2005) 7959-7962. 25. Nielsen,T.E., Le Quement,S., and Meldal,M., Solid-Phase synthesis of bicyclic dipeptide mimetics by intramolecular reactions of alcohols, thiols, amines and amides with cyclic n-acyliminium intermediates, Org. Lett., 17 (2005) 3601-3604. 26. Benito,J.M., Christensen,C.A., and Meldal,M., Versatile solid-phase synthesis of peptide-derived 2-oxazolines. Application in the synthesis of ligands for asymmetric catalysis, Org. Lett., 7 (2004) 581-584. 27. Benito,J.M. and Meldal,M., Bicyclic organo-peptides as selective carbohydrate receptors: Design, solid-phase synthesis, and on-bead binding capability, QSAR & Combinatorial Science, 23 (2004) 117-129. 28. Bukrinsky,J.T., St.Hilaire,P.M., Meldal,M., Crocker,P.R., and Henriksen,A., Complex of Sialoadhesin (Siglec-1) with a glycopeptide ligand, Biochem. Biophys. Acta., 1702 (2004) 173-179. 29. Christensen,C., Tornøe,C.W., and Meldal,M., Pyrazines on solid support from peptides by periodinane oxidation of threonine side-chains. A quantitative chemical transformation (QCT) for combinatorial chemistry, Combinatorial Science, 23 (2004) 109-116. 30. Christensen,C.A. and Meldal,M., Efficient Solid-Phase Synthesis of Peptide Based Phosphine Ligands: Towards Combinatorial Libraries of Selective Transition Metal Catalysts, Chem. Eur. J., 11 (2004) 4121-4131. 31. Diness,F., Beyer,J., and Meldal,M., Synthesis of 3-Boc-(1,3)-oxazinane Protected Amino Aldehydes. Synthesis from Amino Acids and their conversion into Urea Precursors. Novel Building Blocks for Combinatorial Synthesis, QSAR & Combinatorial Science, 23 (2004) 130-144. 32. Fieber,W., Kragelund,B.B., Meldal,M., and Poulsen,F.M., Reversible dimerization of acid-denatured ACBP controlled by helix A4, Biochemistry, 44 (2004) 1375-1384. 33. Juliano,M.A., Brooks,D.R., Selzer,P.M., Pandolfo,H.L., Judice,W.A.S., Juliano,L., Meldal,M., Sanderson,S.J., Mottram,J.C., and Coombs,G.H., Differences in substrate specificities between cycsteine protease CPB isoforms of Leishmania mexicana mediated by few amino acid changes, Eur. J. Biochem., 271 (2004) 3704-3714. 34. Meldal,M., One bead two compound libraries" for detecting chemical and biochemical conversions., Curr. Opin. Chem. Biol., 8 (2004) 238-244. 37. Nielsen,T.E. and Meldal,M., Solid-Phase Intramolecular N-Acyliminium Pictet-Spengler Reactions as Crossroads to Scaffold Diversity, J. Org. Chem., 69 (2004) 3765-3773. 38. Papanikos,A. and Meldal,M., -keto amide peptides: a synthetic strategy to resin-bound peptide isosters for protease inhibitor screening on solid support, J. Comb. Chem, 6 (2004) 181-195. 39. Roice,M., Meldal,M., and Christensen,S.F., Ultramine: A high capacity polyethylene amine-based polymer and its application as a scavenger resin, Chem. Eur. J., 10 (2004) 4407-4415. 40. Roice,M., Johansen,I., and Meldal,M., High capacity poly(ethylene glycol) based amino polymers for peptide and organic synthesis, QSAR & Combinatorial Science, 23 (2004) 662-673. 41. Tornøe,C.W., Sanderson,S.J., Mottram,J.C., Coombs,G.H., and Meldal,M., Combinatorial Library of Peptidotriazoles: Identification of Novel [1,2,3]-Triazole Inhibitors against a Recombinant Leishmania mexicana Cysteine Protease, J. Comb. Chem., 6 (2004) 312-324. 42. Bondebjerg,J., Grunnet,M., Jespersen,T., and Meldal,M., Solid Phase Synthesis and Biological Activity of a Thioether Analog of Conotoxin G1, ChemBiochem , 4 (2003) 186-194. 43. Christensen,C., Schiødt,C.B., Foged,N.T., and Meldal,M., Solid phase combinatorial library of 1,3-azole containing peptides for the discovery of matrix metallo proteinase inhibitors, Combinatorial Science, 22 (2003) 754-766. 46. Halkes,K., St.Hilaire,P.M., Crocker,P.R., and Meldal,M., Glycopeptides as oligosaccharide mimics: High affinity sialopeptide ligands for Sialoadhesin from combinatorial libraries., J. Comb. Chem., 5 (2003) 18-27. 49. Mouritsen,S., Meldal,M., Ruud-Hansen,J., and Werdelin,O., Protein segments with primary structures resistant towards some proteolytic enzymes seem to be good T-cell immunogenic determinants, TBD, (2003). 50. Nielsen,T.E., Diness,F., and Meldal,M., The pictet spengler reaction in solid-phase combinatorial chemistry, Current Opinion in Drug Discovery & Development, 6 (2003) 801-814. 55. Willert,M., Benito,J.M., and Meldal,M., Solid phase combinatorial library of norstatine-type isosters by the nitroaldol reaction, J. Comb. Chem., 5 (2003) 91-101. 56. Bondebjerg,J., Xiang,Z., Bauzo,R.M., Haskell-Luevano,C., and Meldal,M., A solid phase approach to mouse melanocortin receptor agonists derived from a novel thioether cyclized peptidomimetic scaffold, J. Am. Chem. Soc., 124 (2002) 11046-11055. 57. Bondebjerg,J., Meldal,M., Bauzo,R.M., and Haskell-Luevano,C., A novel solid phase approach to thioether cyclized peptides: Discovery of mouse melanocortin receptor agonists, Peptides 2001, Proc. Am. Pept. Symp., (2002) 271-272. 58. Buchardt,J. and Meldal,M., Novel methodology for solid phase synthesis of phosphinic peptides, Proc. 6'th Chinese Pept. Symp , Shanghai (2001), (2002) 73-75. 59. Campos,S.V., Miranda,L.P., and Meldal,M., Preparation of novel O-sulfated amino acid building blocks with improved acid stability for Fmoc-based solid-phase peptide synthesis, J. Chem. Soc. , Perkin Trans. 1, (2002) 682-686. 60. Christensen,C., Groth,T., Schiødt,C.B., Foged,N.T., and Meldal,M., Automated sorting of beads from a "one -bead-two-compounds" combinatorial library of metalloproteinase inhibitors, Combinatorial Science, 22 (2002) 737-744. 61. Christensen,C. and Meldal,M., Oxidation of threonine and serine residues on solid-phase. Pyrazine formation by Dess-Martin periodane oxidation, Peptides 2001, Proc. Am. Pept. Symp., (2002) 269-270. 62. Gad,M., Werdelin,O., Meldal,M., Komba,S. , and Jensen,T., Characterization of T cell hybridomas raised against a glycopeptide containing the tumor-associated T antigen, (Gal (1-3) GalNAc-O/Ser), Glycoconjugate journal., 19 (2002) 59-65. 63. Gad,M., Gagne,R., Jensen,T., Komba,S., Meldal,M., Daugaard,S., Kroman,N., and Werdelin,O., MUC1-derived glycopeptide libraries with improved MHC anchors are strong antigens and prime mouse T cells for proliferative response to lysates of human breast cancer tissue, Eur. J. Immunol., (2002) 1624-1632. 64. Gagne,R., Komba,S., Jensen,T., Gad,M., Werdelin,O., and Meldal,M., Determining the fate of glycopeptides during antigen processing in antigen presenting cells, Peptides 2001, Proc. Am. Pept. Symp., (2002) 1041-1042. 65. Graven Sams,A., Grøtli,M., and Meldal,M., Solid phase aldol reactions on polyoxyethylene-polyoxypropylene (POEPOP) resin. Incorporation of aldol fragments into peptides as isosteric elements. In: Epton,R. (Ed.), Innovation and perspectives in solid phase synthesis & combinatorial libraries, Mayflower Worldwide Limited, Kingswinford, 2002, pp. 351-354. 66. Jansson,A.M., Grøtli,M., Halkes,K.M., and Meldal,M., Palladium on carbon encapsulated in POEPOP1500: A resin-supported catalyst for hydrogenation reactions, Org. Lett., 4 (2002) 27-30. 67. Meldal,M., The One-bead Two-Compound Assay for Solid Phase Screening of Combinatorial Libraries, Biopolymers, Peptide Science, 66 (2002) 93-100. 68. Meldal,M. and Pirrung,M., Combinatorial Chemistry, Overview, Curr. Opin. Chem. Biol., 6 (2002) 287-288. 69. Miranda,L.P. and Meldal,M., UniChemo Protection (UCP). In: Peptides 2001, Proc.Am.Pept.Symp. 2002, pp. 58-60. 70. Miranda,L.P., Lubell,W.D., Halkes,K.M., Gotfredsen,C.H., and Meldal,M., SPOCC 194, A new high functional group density PEG-based resin for solid phase organic synthesis, J. Comb. Chem., (2002) 523-529. 71. Schulte Herbrüggen,T., Meissner,A., Papanikos,A., Meldal,M., and Sørensen,O.W., Optimizing delays in MBOB, broadband NMBC, and broadband XLOC NMR pulse sequences, J. Magn. Resonance, 156 (2002) 282-294. 72. St.Hilaire,P.M., Alves,L.C., Herrera,F., Renil,M., Sanderson,S.J., Mottram,J.C., Coombs,G.H., Juliano,M., Juliano,L., Arevalo,J., and Meldal,M., Solid-phase library synthesis, screening and selection of tight-binding reduced peptide bond inhibitors of a recombinant Leishmania mexicana cysteine protease B., J. Med. Chem., 45 (2002) 1971-1982. 73. Tornøe,C.W., Christensen,C., and Meldal,M., Bioteknologi og kombinatorisk kemi, Dansk Kemi, Tillæg, (2002) 24-26. 74. Tornøe,C.W., Christensen,C., and Meldal,M., Peptidotriazoles on solid-phase: [1,2,3]-Triazoles by regiospecific copper(I)-catalyzed 1,3-dipolar cycloadditions of terminal alkynes to azides, J. Org. Chem., (2002) 3057-3064. 75. Tornøe,C.W. and Meldal,M., EXPO3000- a new expandable polymer for synthesis and enzymatic assays, Tetrahedron Lett., 43 (2002) 6409-6411. 76. Werdelin,O., Meldal,M., and Jensen,T., Processing of glycans on glycoprotein and glycopeptide antigens in antigen presenting cells, PNAS, 99 (2002) 9611-9613. 77. Alves,L.C., Judice,W.A.S., St.Hilaire,P.M., Meldal,M., Sanderson,S.J., Mottram,J.C., Coombs,G.H., Juliano,L., and Juliano,M.A., Substrate specificity of recombinant cysteine proteinase, CPB, of Leishmania mexicana, Molec. Biochem. Parasitol., 116 (2001) 1-9. 78. Alves,L.C., Hilaire,P.M.St., Meldal,M., Sanderson,S.J., Mottram,J.C., Coombs,G.H., Juliano,L., and Juliano,M.A., Identification of peptides inhibitory to recombinant cysteine proteinase, CPB, of Leishmania mexicana, Molec. Biochem. Parasitol., 114 (2001) 81-88. 81. Graven Sams,A., St.Hilaire,P.M., Sanderson,S.J., Mottram,J.C., Coombs,G.H., and Meldal,M., A Combinatorial Library of Peptide Isosters based on Diels-Alder Reactions: Identification of Novel Inhibitors Against a Recombinant Cysteine Protease from Leishmania mexicana, J. Comb. Chem., 3 (2001) 441-452. 82. Graven Sams,A. and Meldal,M., Peptido-organic Diels-Alder reactions on hydrophilic resin: scope for combinatorial chemistry, Perkin 1, (2001) 3198-3203. 83. Groth,T. and Meldal,M., Resin bound N-terminal peptide aldehydes: Formation and application as electrophiles in the combinatorial syntheses of peptidomimetics. In: Jean,M., Fehrentz,J.-A. (Eds.), EDK, Paris, 2001, pp. 981-982. 84. Groth,T. and Meldal,M., Synthesis of Aldehyde Building Blocks Protected as Acid Labile N-Boc N,O-Acetals; Towards Combinatorial Solid Phase Synthesis of Novel Peptide Isosteres., J. Comb. Chem., 3 (2001) 34-44. 85. Groth,T. and Meldal,M., N-Terminal Aldehydes as Electrophiles in Combinatorial Solid Phase Synthesis of Novel Peptide Isosteres., J. Comb. Chem., 3 (2001) 45-63. 86. Groth,T., Grøtli,M., and Meldal,M., Diffusion of Reagents in Macrobeads., J. Comb. Chem., 3 (2001) 461-468. 87. Grøtli,M., Rademan,J., Groth,T., Lubell,W., Miranda,L.P., and Meldal,M., Surfactant mediated cationic and anionic suspension polymerization of PEG-based resins in silicon oil; beaded SPOCC 1500 and POEPOP 1500, J. Comb. Chem., 3 (2001) 28-33. 88. Halkes,K., Gotfredsen,C.H., Grøtli,M., Miranda,L.P., Duus,J.Ø., and Meldal,M., Solid phase glycosylation of peptide templates and on-bead MAS-NMR analysis: Perspectives for glycopeptide libraries, Chemistry, Eur. J., (2001) 3584-3591. 89. Jensen,T., Nielsen,M., Hansen,P., Komba,S., Meldal,M., Ødum,N., and Werdelin,O., Radically altered T-cell receptor signaling in glycopeptide specific T cell hybridoma induced by antigen with minimal differences in the glycan group, Eur. J. Immunol., (2001) 3197-3206. 95. Miranda,L.P. and Meldal,M., Unichemo Protection: A Concept for Chemical Synthesis, Angew. Chem. Int. Ed., 40 (2001) 3653-3655. 96. Papanikos,A., Rademann,J., and Meldal,M., -Ketocarbonyl peptides: A general approach to reactive resin bound intermediates in the synthesis of peptide isosteres for protease inhibitor screening on solid support, J. Am. Chem. Soc., 123 (2001) 2176-2181. 97. Schiødt,C.B., Buchardt,J., Terp,G.E., Christensen,U., Brink,M., Larsen,Y.B., Meldal,M., and Foged,N.T., Phosphinic peptide inhibitors of macrophage metalloelastase (MMP-12). Selectivity and mechanism of binding, Curr. Med. Chem., 8 (2001) 967-976. 98. Tornøe,C.W. and Meldal,M., Peptidotriazoles: Copper(I)-catalyzed 1,3-dipolar cycloadditions on solid-phase. In: Lebl,M., Houghten,R.A. (Eds.), American Peptide Society and Kluwer Academic Publishers, San Diego, 2001, pp. 263-264. 99. Buchardt,J. and Meldal,M., Novel methodology for the solid-phase synthesis of phosphinic peptides, Perkin 1, (2000) 3306-3310. 100. Buchardt,J., Schiødt,C.B., Ferreras,M., Foged,N.T., Delaissé,J.-M., and Meldal,M., Combinatorial library of phosphinic peptides for discovery of MMP inhibitors on solid phase. In: Fields,G.B., Tam,J.P., Barany,G. (Eds.), Peptides for the new millenium, Proc. 16'th Am. Pept. Symp. 1999, Kluwer Academic Publishers, Dordrecht, 2000, pp. 443-444. 101. Buchardt,J., Schiødt,C.B., Krog-Jensen,C., Delaisse,J.-M., Foged,N.T., and Meldal,M., Solid phase combinatorial library of phosphinic peptides for discovery of matrix metalloproteinase inhibitors, J. Comb. Chem., 2 (2000) 624-638. 102. Cipolla,L. and Meldal,M., Synthesis of a non-natural T-antigen containing glycosphingolipid, Carbohydr. Lett., 4 (2000) 29-34. 103. Franco,A., Tilly,A.D., Gramaglia,I., Croft,M., Cipolla,L., Meldal,M. , and Grey,H.M., Epitope affinity for MHC class I determines helper requirement for CTL priming, Nature Immunology, 1 (2000) 145-150. 104. Gotfredsen,C.H., Grøtli,M., Willert,M., Meldal,M., and Duus,J.Ø., Single-bead structure elucidation. Requirements for analysis of combinatorial solid-phase libraries by nanoprobe MAS-NMR spectroscopy, J. Chem. Soc. ,Perkin Trans. 1, (2000) 1167-1171. 105. Graven Sams,A., Grøtli,M., and Meldal,M., Towards peptide isostere libraries: aqueous aldol reactions on hydrophylic solid supports, Perkin 1, (2000) 955-962. 106. Groth,T., Grøtli,M., Lubell,W.D., Miranda,L.P., and Meldal,M., Novel concept of resin polymerization: Preparation of HYDRA - a bifunctional PEG-based resin by reductive amination, Pept. Proc. 26. Eur. Pep. Symp. , 2000 Montpellier (2001), (2000) 223-224. 107. Groth,T., Meldal,M., and Bock,K., Backbone Amide Protection in Solid-Phase Synthesis of Peptide Isosters Derived from N-Terminal -Aldehydes. In: Fields,G.B., Tam,J.P., Barany,G. (Eds.), Peptides for the new millenium, Proc. 16'th Am. Pept. Symp. 1999, Kluwer Academic Publishers, Dorsdrect, 2000, pp. 146-147. 108. Groth,T., Grøtli,M., Lubell,W.D., Miranda,L.P., and Meldal,M., HYDRA: A Novel Hydroxy and Amine Functionalised Resin Synthesised by Reductive Amination of PEG Aldehyde and a Polyamine., Perkin 1, (2000) 4258-4264. 109. Grøtli,M., Gotfredsen,C.H., Rademann,J., Duus,J.Ø., and Meldal,M., Chemical and physical properties of PEG based resins, J. Comb. Chem, 2 (2000) 108-119. 110. Grøtli,M., Gotfredsen,C.H., Rademann,J., Buchardt,J., Clark,A.J., Duus,J.Ø., and Meldal,M., Physical Properties of PEG-Based Resins for Solid Phase Organic Chemistry: A Comparison of PEG Cross-Linked and PEG Grafted Resins . In: Epton,R. (Ed.), Innovation and Perspectives in Solid Phase Synthesis and Combinatorial Libraries, Mayflower, Kingwinford (2001), 2000, pp. 109-112. 111. Halkes,K.M., St.Hilaire,P.M., Jansson,A.M., Gotfredsen,C.H., and Meldal,M., Synthesis and application of sialic acid-containing building blocks for glycopeptide libraries.1 Establishing the glycosidation conditions., Perkin 1, (2000) 2127-2133. 112. Jensen,T., Hansen,P., Gad,M., Meldal,M. , Komba,S., and Werdelin,O., Characterization of T cell hybridomas raised against a glycopeptide containing the tumor associated T antigen, Ser(Gal(1-3)--GalNAc-O-), Eur. J. Immunol., 29 (2000) 2759-2768. 113. Komba,S., Werdelin,O., Jensen,T., and Meldal,M., Synthesis of tumor associated sialyl-T-glycopeptides and their immunogenicity, J. Peptide Sci., 6 (2000) 585-593. 114. Meldal,M., St.Hilaire,P.M., Willert,M., Rademann,J., Grötli,M., Buchardt,J., Gotfredsen,C.H., Juliano,M.A., and Juliano,L., Investigation of enzyme activity and inhibition in the interior of novel solid supports. In: Proc.5'th Chinese Pept.Symp., Lanchou 1998, Kluwer Academic Publishers, Dordrecth, 2000, pp. 14-19. 115. Meldal,M., Rademann,J., Grötli,M., Buchardt,J., Gotfredsen,C.H., Halkes,K., Graven Sams,A., Duus,J.Ø., Miranda,L.P., and St.Hilaire,P.M., SPOCC resins: polar and chemically inert resins for organic synthesis and enzyme library assays. In: Fields,G.B., Tam,J.P., Barany,G. (Eds.), Peptides for the new millenium , Proc. 16'th Am. Pept. Symp. 1999, Kluwer Academic Publishers, Dordrecht, 2000, pp. 176-178. 116. Rademann,J., Grötli,M., and Meldal,M., The SPOCC-resin - Preparation and use for organic chemistry, enzymatic reactions and combinatorial synthesis of peptide isostere libraries. In: Epton,R. (Ed.), Innovation and Perspectives in Solid Phase Synthesis and Combinatorial Libraries, Mayflower, Kingwinsford, 2000, pp. 33-36. 117. Sanderson,S., Pollock,K., Hilley,J., Meldal,M., St.Hilaire,P.M., Juliano,M.A., Juliano,L., Mottram,J.C., and Coombs,G.H., Expression and characterisation of a recombinant cysteine protease of Leishmania Mexicana, Biochem J., 347 (2000) 383-388. 118. St.Hilaire,P.M., Sanderson,S., Juliano,M.A., Willert,M., Mottram,J.C., Coombs,G.H., Juliano,L., and Meldal,M., A combinatorial approach to the identification of cysteine protease substrates and inhibitors by application of a solid-phase fluorescence quenching assay. In: Fields,G.B., Tam,J.P., Barany,G. (Eds.), Peptides for the new millenium, Proc. 16'th Am. Pept Symp., 1999, Kluwer Academic Publishers, Dordrecht, 2000, pp. 456-458. 119. St.Hilaire,P.M. and Meldal,M., Glycopeptide and Oligosaccharide Libraries, Angew. Chem. Int. Ed. Engl., 39 (2000) 1163-1179. 120. St.Hilaire,P.M., Alves,L.C., Sanderson,S.J., Mottram,J.C., Juliano,M.A., Coombs,G.H., and Meldal,M., The substrate specificity of a recombinant cysteine protease from Leishmania mexicana: application of a combinatorial peptide library approach, ChemBiochem., 1 (2000) 115-122. 121. Stennicke,H.R., Renatus,M., Meldal,M., and Salvesen,G.S., Internally quenched fluorescent peptide substrates disclose the subsite preferences of human caspases 1,3,6,7 and 8, Biochem. J., 350 (2000) 563-568. 122. Tornøe,C.W., Davis,P., Porreca,F., and Meldal,M., -Azido acids for direct use in solid-phase peptide synthesis, J. Peptide Sci., (2000) 594-602. 123. Tornøe,C.W., Sengeløv,H., and Meldal,M., Solid-phase synthesis of chemotactic peptides using -azido acids, J. Peptide Sci., 6 (2000) 314-320. 124. Tornøe,C.W. and Meldal,M., EXPO3000 - A new expandable polymer for organic synthesis and enzymatic assays. In: Martinez,J., Fehrentz,J.-A. (Eds.), Peptides 2000, EDK, Paris, 2000, pp. 281-282. 125. Tornøe,C.W., Sonke,T., Maes,I., Schoemaker,H.E., and Meldal,M., Enzymatic and chiral HPLC resolution of -azido acids and amides, Tetrahedron Assym., 11 (2000) 1-10. 126. Buchardt,J., Ferreras,M., Krog-Jensen,C., Delaisse,J.-M., Foged,N.T., and Meldal,M., Phosphinic matrix metalloproteinase-9 inhibitors by solid-phase synthesis using a building block approach, Chem. Eur. J., 5 (1999) 2877-2884. 129. Duus,J.Ø., St.Hilaire,P.M., Meldal,M., and Bock,K., Carbohydrate chemistry synthetic and structural challenges towards the end of the 20th century, Pure Appl. Chem., 71 (1999) 755-765. 130. Jansson,A.M. and Meldal,M., Azido acids in a novel method of automated solid phase synthesis, Pept. 1998,. Proc. Eur. Pept. Symp. , 25th, (1999) 94-95. 131. Komba,S., Meldal,M., Werdelin,O., Jensen,T., and Bock,K., Convenient synthesis of Thr and Ser carrying the tumor associated sialyl-(2-3)- antigen as building blocks for solid-phase glycopeptide synthesis, J. Chem. Soc. , Perkin Trans. 1, (1999) 415-419. 132. Krog-Jensen,C., Christensen,M.K., and Meldal,M., Preparation of an unprotected phosphotyrosine building block and its application in solid-phase synthesis of phosphopeptides, Peptide Lett., 6 (1999) 1-5. 133. Mehta,S., Meldal,M., Duus,J.Ø., and Bock,K., Evaluation of the effect of glycosylation on the enzymic hydrolysis of peptides, J. Chem. Soc., (1999) 1445-1451. 134. Meldal,M., Parallel personal comments on "classical" papers in combinatorial chemistry. In: Lebl,M. (Ed.), J. Combi. Chem. 1999, pp. 3-24. 135. Rademann,J., Grötli,M., Meldal,M., and Bock,K., SPOCC: a resin for solid phase organic chemistry and enzyme reactions in solid phase, J. Am. Chem. Soc., 121 (1999) 5459-5466. 136. St.Hilaire,P.M., Willert,M., Juliano,M.A., Juliano,L., and Meldal,M., Fluorescence-quenched solid phase combinatorial libraries in the characterization of cysteine protease substrate specificity, J. Comb. Chem., 1 (1999) 509-523. 137. St.Hilaire,P.M., Meldal,M., and Bock,K., Analysis of O- and N-linked glycopeptide libraries by MALDI-TOF MS: application in solid phase assays of carbohydrate binding proteins, Peptides 1997, Proc. Am. Pept. Symp., (1999) 45-46. 138. St.Hilaire,P.M., Cipolla,L., Franco,A., Tedebark,U., Tilly,A.D., and Meldal,M., Synthesis of T-antigen containing glycopeptides as potential cancer vaccines, Perkin 1, (1999) 3559-3564. 139. Auzanneau,F.-I., Christensen,M.K., Harris,S.L., Meldal,M., and Pinto,B.M., Synthesis and characterization of polyethylene glycol polyacrylamide copolymer (PEGA) resins containing carbohydrate ligands. Evaluation as supports for affinity chromatography, Can. J. Chem., 76 (1998) 1109-1118. 140. Buchardt,J. and Meldal,M., A chemically inert hydrophilic resin for solid phase organic synthesis, Tetrahedron Lett., 39 (1998) 8695-8698. 141. Davy,A., Svendsen,I., Sørensen,S.O., Sørensen,M.B., Rouster,J., Meldal,M., Simpson,D.J., and Cameron-Mills,V., Substrate specificity of two barley cysteine endoproteases EP-A and EP-B, Plant Physiol., 117 (1998) 255-261. 142. Duus,J.Ø., Meldal,M., and Winkler,J.R., Fluorescence energy-transfer probes of conformation in peptides: The 2-aminobenzamide/nitrotyrosine pair, J. Phys. Chem. B, 102 (1998) 6413-6418. 143. Frank,L. and Meldal,M., Tre millioner nye stoffer på ganske få dage. In: Ingeniøren 1998. 144. Hilaire,P.M.St., Lowary,T.L., and Meldal,M., Oligosaccharide mimetics obtained by novel, rapid screening of carboxylic acid encoded glycopeptide libraries, J. Am. Chem. Soc., 120 (1998) 13312-13320. 145. Ito,A.S., Turchiello,R.F., Hirata,I.Y., Cezari,M.H., Meldal,M., and Juliano,L., Flourescent properties of amino acids labelled with ortho-amino benzoic acid, Biospectroscopy, 4 (1998) 395-402. 146. Jensen,T., Hansen,P., Nielsen,A.F., Meldal,M., Komba,S., and Werdelin,O., Shared structural motifs in T cell receptors of glycopeptide recognizing T-cell hybridomas, Eur. J. Immunol., 29 (1998) 2759-2768. 147. Lowary,T., Meldal,M., Helmboldt,A., Vasella,A., and Bock,K., Novel type of rigid C-linked glycosylacetylene phenylalanine building blocks for combinatorial synthesis of C-linked glycopeptides, J. Org. Chem., 63 (1998) 9657-9668. 148. Meldal,M., Renil,M., Juliano,M.A., Jansson,A.M., Meinjohanns,E., Buchardt,J., and Schleyer,A., Novel PEG-based resins and synthetic methods: Azido acids in SPPS and direct solid-phase peptide glycosylations. In: Epton,R. (Ed.), Peptides 1996, Proc. Eur. Pept. Symp., Mayflower Scientific, Kingswinford, UK, 1998, pp. 141-152. 151. Meldal,M., Svendsen,I., Juliano,L., Juliano,M.A., Del Nery,E., and Scharfstein,J., Inhibition of cruzipain visualized in a fluorescence quenched solid-phase inhibitor library. D-Amino acid inhibitors for cruzipain, cathepsin B and cathepsin L., J. Peptide Sci., 4 (1998) 83-91. 152. Meldal,M., Rademann,J., Grötli,M., and Bock,K., Identification of protease inhibitors using biocompatible resins and library synthesis. In: Scolastico,C., Nicotra,F. (Eds.), Current Trends in Organic Synthesis, Kluwer academic/Plenum Publishers, New York, 1998, pp. 77-83. 153. Meldal,M., Meinjohanns,E., Frische,K., Jensen,T., Hansen,P., Werdelin,O., Galli-Stampino,L., Mouritsen,S., and Bock,K., Libraries of synthetic glycopeptides in the characterization of the T-cell response to tumor associated mucin antigens. In: Xu,X.-J., Ye,Y.-H., Tam,J.P. (Eds.), Peptides, Biology and Chemistry, Kluwer Academic Publishers, Dordrecht, 1998, pp. 59-62. 154. Meldal,M., The solid-phase enzyme inhibitor library assay. In: Cabilly,S. (Ed.), Combinatorial peptide library protocols, Humana Press, Totowa, New Jersey, 1998, pp. 75-82. 155. Meldal,M., Introduction to Combinatorial solid phase assay for enzyme activity and inhibition. In: Shmuel,C. (Ed.), Combinatorial Peptide Libraries, Humana Press, Totowa, New Jersey, 1998, pp. 51-82. 156. Meldal,M., Preparation of biocompatible resins for library syntheses. In: Cabilly,S. (Ed.), Combinatorial Peptide Library Protocols, Humana Press, Totowa, New Jersey, 1998, pp. 59-63. 157. Meldal,M., St.Hilaire,P.M., and Bock,K., Solid phase libraries of glycopeptide templates in the study of complex oligosaccharide-receptor interactions. In: Diedrichs,N., Hunzer,H. (Eds.), Recent Trends in Molecular Recognition: The Ernst Schering Research Foundation Workshop 26, Springer-Verlag, Berlin, 1998, pp. 169-182. 158. Meldal,M., Intramolecular fluorescence-quenched substrate libraries. In: Cabilly,S. (Ed.), Combinatorial peptide library protocols, Humana Press, Totowa, New Jersey, 1998, pp. 65-74. 159. Parolis,L.A.S., Parolis,H., Kenne,L., Dell A., Meldal,M., and Bock,K., The extracellular polysaccharide of Pichia (Hansenula) holstii NRRL Y2448: The phosphorylated side chains., Carbohydr. Res., 309 (1998) 77-87. 160. Rademann,J., Meldal,M., and Bock,K., Novel polar resins for solid phase organic chemistry and enzymatic on-bead assays. Towards new peptide isoster libraries. In: Epton,R. (Ed.), Innovation and perspecties in solid phase synthesis and combinatorial libraries Kingswinford, 1998, pp. 38-39. 161. Rademann,J., Meldal,M., and Bock,K., Solid phase synthesis of peptide isosters via nucleophilic reactions with N-terminal peptide aldehydes on a polar support tailored for solid phase organic chemistry, Chem. Eur. J., 5 (1998) 1218-1225. 162. Renil,M., Ferreras,M., Delaisse,J.M., Foged,N.T., and Meldal,M., PEGA supports for combinatorial peptide synthesis and solid-phase enzymatic library assays, J. Peptide Sci., 4 (1998) 195-210. 163. Spetzler,J.C., Westphal,V., Winther,J.R., and Meldal,M., Preparation of fluorescence quenched libraries containing inter-chain disulfide bonds for studies of protein disulfide isomerases, J. Peptide Sci., 4 (1998) 128-137. 164. Spetzler,J.C., Meldal,M., Felding,J., Vedsø,P., and Begtrup,M., Novel acylation catalysts in peptide synthesis: Derivatives of N-hydroxytriazoles and N-hydroxytetrazoles, J. Chem. Soc. , Perkin Trans. 1, (1998) 1727-1732. 165. St.Hilaire,P.M., Lowary,T.L., Meldal,M., and Bock,K., Oligosaccharide mimetics obtained by novel, rapid screening of carboxylic acid encoded glycopeptide libraries, J. Am. Chem. Soc., 120 (1998) 13312-13320. 166. St.Hilaire,P.M., Cipolla,L., Tedebark,U., and Meldal,M., Analysis of organic reactions by thin layer chromatography combined with matrix assisted laser desorption/ionization time-of-flight mass spectrometry, Rap. Comm. Mass. Spec., 12 (1998) 1475-1484. 167. Tedebark,U., Meldal,M., Panza,L., and Bock,K., C-linked glycosyl azido acid in novel solid-phase C-glycopeptide synthesis, Tetrahedron Lett., 39 (1998) 1815-1818. 168. Westphal,V., Spetzler,J.C., Meldal,M., Christensen,U., and Winther,J.R., Kinetic analysis of the mechanism and specificity of protein-disulfide isomerase using fluorescence-quenched peptides, J. Biol. Chem., 273 (1998) 24992-24999. 169. Del Nery,E., Juliano,M.A., Meldal,M., Svendsen,I., Scharfstein,J., Walmsley,A., and Juliano,L., Characterization of substrate specificity of the major cysteine protease (cruzipain) from Trypanosoma cruzi using a portion-mixing combinatorial library and fluorogenic peptides, Biochem. J., 323 (1997) 427-433. 170. Franzyk,H., Christensen,M.K., Jørgensen,M., Meldal,M., Cordes,H., Mouritsen,S., and Bock,K., Constrained glycopeptide ligands for MPRs. Limitations of unprotected phosphorylated building blocks, Bioorg. Med. Chem., 5 (1997) 21-40. 171. Galli-Stampino,L., Meinjohanns,E., Frische,K., Meldal,M., Jensen,T., Werdelin,O., and Mouritsen,S., T-cell recognition of tumor-associated carbohydrates: The nature of the glycan moiety plays a decisive role in determining glycopeptide immunogenicity, J. Cancer. Res., 57 (1997) 3214-3222. 172. Jansson,A.M., Jensen,K.J., Meldal,M., and Bock,K., Solid phase glycopeptide synthesis of tyrosine glycosylated glycogenin fragments. In: Epton,R. (Ed.), Innovations and Perspectives in Solid Phase Synthesis, Mayflower Worldwide, Kingwindsford, 1997, pp. 423-426. 173. Jensen,T., Hansen,P., Galli-Stampino,L., Mouritsen,S., Frische,K., Meinjohanns,E., Meldal,M., and Werdelin,O., Carbohydrate and peptide specificity of MHC class II restricted T cell hybridomas raised an O-glycosylated self-peptide., J. Immunol., (1997) 3769-3778. 174. Juliano,M.A., Nery,E.D., Scharfstein,J., Meldal,M., Svendsen,I., Walmsley,A., and Juliano,L., Characterization of substrate specificity of the major cysteine protease (cruzipain) from Trypanosoma cruzi, Biochem. J., 323 (1997) 427-433. 175. Juliano,M.A., Nery,E.D., Scharfstein,J., Meldal,M., Svendsen,I., Walmsley,A., and Juliano,L., Characterization of substrate specificity of the major cysteine protease (cruzipain) from Trypanosoma cruzi: comparison to human cathepsin B and L. In: Ramage,R., Epton,R. (Eds.), Peptides 1996, Mayflower Scientific, Kingswindford, 1997, pp. 511-512. 176. Klich,G., Paulsen,H., Meyer,B., Meldal,M., and Bock,K., Synthesis and characterization of highly glycosylated glycopeptides with Tn antigenic structures corresponding to human glycophorin AN, Carbohydr. Res., 299 (1997) 33-48. 177. Lay,L., Meldal,M., Nicotra,F., Panza,L. , and Russo,G., Stereoselective synthesis of the C-analogue of -D-glucopyranosyl serine, Chem. Commun., (1997) 1469-1470. 178. Mathieux,N., Paulsen,H., Meldal,M., and Bock,K., Synthesis of glycopeptide sequences of repeating units of the MUC 2 and MUC 3 containing oligosaccharide side chains with core 1, core 2, core 3, core 4 and core 6 structure, J. Chem. Soc. , Perkin Trans. 1, (1997) 2359-2368. 179. Meinjohanns,E., Meldal,M., Paulsen,H., Dwek,R.A., and Bock,K., Novel sequential solid-phase synthesis of N-linked glycopeptides from natural sources, J. Chem. Soc. , Perkin Trans. 1 , 3 (1997) 549-560. 180. Meinjohanns,E., Meldal,M., Jensen,T., Werdelin,O., Galli-Stampino,L., Mouritsen,S., and Bock,K., Versatile solid-phase thiolytic reduction of azido and N-Dts groups in the synthesis of haemoglobin (67-76) O-glycopeptides and photoaffinity labelled analogs to study glycan T-cell specificity, J. Chem. Soc. , Perkin Trans. 1, (1997) 871-884. 181. Meldal,M. and St.Hilaire,P.M., Synthetic methods of glycopeptide assembly, and biological analysis of glycopeptide products, Curr. Opin. Chem. Biol., 1 (1997) 552-563. 182. Meldal,M., Franzyk,H., Meinjohanns,E., Vargas-Berenguel,A., Frische,K., Christensen,M.K., Christiansen-Brams,I., Jensen,K.J., and Bock,K., Recent techniques in glycopeptide synthesis and biology: The glycopeptide templates. In: Epton,R. (Ed.), Innovation and Perspectives Solid Phase Synthesis, Mayflower worldwide, Kingwindsford, 1997, pp. 263-268. 183. Meldal,M., Juliano,M.A., and Jansson,A.M., Azido acids in a novel method of solid-phase peptide synthesis, Tetrahedron Lett., 38 (1997) 2531-2534. 184. Meldal,M., Tornøe,C.W., Tedebark,U., Jansson,A.M., Juliano,M.A., Panza,L., and Lay,L., Azido acids in a novel method of solid phase synthesis. In: Epton,R. (Ed.), Innovation and Perspectives in Solid Phase Synthesis, Mayflower Scientific, Kingwinford, UK, 1997, pp. 19-22. 185. Meldal,M., Properties of the solid support. In: Fields,G. (Ed.), Methods in Enzymology: Solid-Phase Peptide Synthesis, Academic Press, London, 1997, pp. 83-104. 186. Metha,S., Meldal,M., Ferro,V., Duus,J.Ø., and Bock,K., Internally quenched fluorogenic, -helical dimeric peptides and glycopeptides for the evaluation of the effect of glycosylation on the conformation of peptides, J. Chem. Soc. , Perkin Trans. 1, (1997) 1365-1374. 187. Paulsen,H., Schleyer,A., Mathieux,N., Meldal,M., and Bock,K., A new solid-phase oligosaccharide synthesis on glycopeptides bound to a solid phase, J. Chem. Soc. , Perkin Trans. 1, (1997) 281-293. 188. Renil,M., Meldal,M., Delaisse,J.-M., and Foged,N., Fluorescent quenched peptide libraries as a tool for identification of enzyme substrates for matrix metalloproteinase (MMP)-9 from osteoclasts. In: Ramage,R., Epton,R. (Eds.), Peptides 1996, Mayflower Scientific, Kingswindford, 1997, pp. 753-754. 189. Schleyer,A., Meldal,M., Renil,M., Paulsen,H., and Bock,K., Direct solid-phase glycosylations of peptide templates on a novel PEG-based resin, Angew. Chem. Int. Ed. Engl., 109 (1997) 2064-2067. 190. Spetzler,J.C. and Meldal,M., Evaluation of Strategies for "one-pot" deprotection-cleavage and disulfide bond formation in the preparation of cysteine-containing peptides, Lett. Pept. Sci., 3 (1997) 327-332. 191. Spetzler,J.C., Meldal,M., Meinjohanns,E., Steinaa,L., Mouritsen,S., and Bock,K., Synthetic hFSH peptide constructs in the evaluation of previous studies on the hFSH receptor interaction, J. Peptide Sci., 3 (1997) 397-414. 192. St.Hilaire,P.M., Lowary,T., Meldal,M., and Bock,K., Synthesis and analysis of glycopeptide libraries and their application in solid phase assays of carbohydrate binding-proteins. In: Ramage,R., Epton,R. (Eds.), Peptides 1996, Proc. Eur. Pept. Symp., Mayflower Scientific, Kingswindford, 1997, pp. 817-818. 193. Brockhausen,I., Toki,D., Brockhausen,J., Peters,S., Bielfeldt,T., Kleen,A., Paulsen,H., Meldal,M., Hagen,F., and Tabak,L.A., Specificity of O-glycosylation by bovine colostrum UDP-GalNAc: polypeptide -N-galactosaminyltransferase using synthetic glycopeptide substrates, Glycoconjugate J., 13 (1996) 849-856. 194. Franzyk,H., Meldal,M., Paulsen,H., Thiel,S., Jensenius,J.C., and Bock,K., Glycopeptide mimics of mammalian Man9GlcNAc2. Ligand binding to mannan-binding proteins(MBPs), Bioorg. Med. Chem., 4 (1996) 1881-1899. 195. Frische,K., Meldal,M., Werdelin,O., Mouritsen,S., Jensen,T., Galli-Stampino,L., and Bock,K., Multiple column synthesis of a library of T-cell stimulating Tn-antigenic glycopeptide analogs for the molecular characterization of glycan T-cell specificity, J. Peptide Sci., 2 (1996) 212-222. 196. Grøn,H., Bech,L.M., Sørensen,S.B., Meldal,M., and Breddam,K., Studies of binding sites in the subtilisin from bacillus lentus by means of site directed mutagenesis and kinetic investigations. In: Bott,R., Betzel,C. (Eds.), Subtilisin Enzymes: Practical Protein Engineering 1996, pp. 105-112. 197. Jansson,A.M., Jensen,K.J., Meldal,M., Lomako,J., Lomako,W.M., Olsen,C.E., and Bock,K., Solid phase glycopeptide synthesis of tyrosine glycosylated glycogenin fragments as substrates for glycosylation by glycogenin, J. Chem. Soc. , Perkin Trans. 1, (1996) 1001-1006. 198. Jensen,T., Galli-Stampino,L., Mouritsen,S., Frische,K., Peters,S., Meldal,M., and Werdelin,O., T cell recognition of Tn-glycosylated peptide antigens, Eur. J. Immunol., 26 (1996) 1342-1349. 199. Löffler,A., Doucey,M.-A., Jansson,A., Müller,D.R., de Beer,T., Hess,D., Meldal,M., Richter,W.J., Vliegenhart,J.F.G., and Hofsteenge,J., Spectroscopic and protein chemical analyses demonstrate the presence of C-mannosylated tryptophan in intact human RNase 2 and its isoforms, Biochemistry, 35 (1996) 12005-12014. 200. Meinjohanns,E., Meldal,M., Paulsen,H., Schleyer,A., and Bock,K., Efficient synthesis of core 1, core 2, core 3 and core 4 building blocks for solid-phase synthesis of mucin glycopeptides, J. Chem. Soc. , Perkin Trans. 1, (1996) 985-993. 203. Meldal,M., Meinjohanns,E., Frische,K., Bock,K., and Paulsen,H., Application of new synthetic methods in studies of immunology of O-linked cytosol- and mucin-glycopeptides. In: Kaumaya,P.T.P. (Ed.), Peptides 1995, Proc. Am. Pept. Symp., 14'th, ESCOM, Leiden, 1996, pp. 421-423. 204. Olesen,K., Meldal,M., and Breddam,K., Extented subsite characterization of carboxypeptidase Y using substrates based on intramolecularly quenched fluorescence, Prot. Pept. Lett., 3 (1996) 67-74. 205. Parolis,L.A.S., Duus,J.Ø., Parolis,H., Meldal,M., and Bock,K., The extracellular polysaccharide of Pichia (Hansenula) holstii NRRL Y-2448: The structure of the phosphomannan backbone., Carbohydr. Res., 293 (1996) 101-117. 206. Peters,S., Meldal,M., and Bock,K., Recent development in glycopeptide synthesis. In: Khan,S.H., O'Neill,R.A. (Eds.), Modern Methods in Carbohydrate Synthesis, Vol. 1, Harwood Academic Publishers Gmbh, Amsterdam, 1996, pp. 352-377. 207. Renil,M. and Meldal,M., POEPOP and POEPS: Inert polyethylene glycol crosslinked polymeric supports for solid phase synthesis, Tetrahedron Lett., 37 (1996) 6185-6188. 208. Spetzler,J.C., Westphal,V., Winther,J.R., and Meldal,M., Fluorescent quenched libraries for monitoring chemical and enzymatic disulfide bond formation and cleavage. In: Tam,J.P. (Ed.), Proceedings of the second Chinese Peptide Symposium, ESCOM, Leiden, 1996, pp. 63-66. 209. Auzanneau,F.-I., Meldal,M., and Bock,K., Synthesis, characterization and biocompatibility of PEGA resins, J. Peptide Sci., 1 (1995) 31-44. 212. Franzyk,H., Meldal,M., and Bock,K., Synthesis of aliphatic O-dimannosyl amino acid building blocks for solid-phase assembly of glycopeptide libraries, J. Chem. Soc. , Perkin Trans. 1, (1995) 2883-2898. 213. Frische,K., Jensen,T., Galli-Stampino,L., Mouritsen,S., Werdelin,O., and Meldal,M., Tumor associated T- and Tn-antigen substitution in an MHC class II binding non-immunogenic epitope by multiple column glycopeptide synthesis. In: Schneider,C.H. (Ed.), Peptides in Immunology, John Wiley and Sons, Ltd., 1995, pp. 219-221. 214. Galli-Stampino,L., Jensen,T., Frische,K., Meldal,M., Werdelin,O., and Mouritsen,S., The role of antigen glycosylation for binding to MHC and for immunogenicity. In: Schneider,C.H. (Ed.), Pept. in Immunol., 1'st Proceedings of a Symposium Under the Auspices of the European Peptide Society, April 2-5, 1995, Interlaken, Switzerland, John Wiley and Sons, New York, 1995. 215. Lellouch,A.C., Peters,S., Arsequell,G., Meldal,M., and Dwek,R.A., Synthesis of an IgA1 hinge region glycopeptide. In: Maia,H.L.S. (Ed.), Peptides 1994, Proc. Twenty-Third Eur. Pept. Symp., ESCOM, Leiden, 1995, pp. 727-728. 216. Meinjohanns,E., Meldal,M., Paulsen,H., and Bock,K., The dithiasuccinoyl (Dts) amino protecting group used in syntheses of 1,2-trans amino sugar glycosides, J. Chem. Soc. , Perkin Trans. 1, (1995) 405-415. 217. Meinjohanns,E., Vargas-Berenguel,A., Meldal,M., and Bock,K., Comparison of N -Dts and N-Aloc in the solid-phase syntheses of O-GlcNAc glycopeptide fragments of RNA-polymerase II and mammalian neurofilaments, J. Chem. Soc. , Perkin Trans. 1, (1995) 2165-2175. 218. Meinjohanns,E., Meldal,M., and Bock,K., Efficient synthesis of O-(2-acetamido-2-deoxy--D- glucopyranosyl)-Ser/Thr building blocks for SPPS of O-GlcNac glycopeptides, Tetrahedron Lett., 36 (1995) 9205-9208. 219. Meldal,M. and Svendsen,I., Direct visualization of enzyme inhibitors using a portion mixing inhibitor library containing a quenched fluorogenic peptide substrate. 1: Inhibitors for subtilisin Carlsberg, J. Chem. Soc. , Perkin Trans. 1, (1995) 1591-1596. 220. Meldal,M., Christensen,M.K., Bock,K., Cordes,H., and Mouritsen,S., Phosphorylated glycopeptide templates as high affinity ligands for the Man-6-P receptor. In: Maia,H.L.S. (Ed.), Peptides 1994, Proc. Eur. Pept. Symp., 23'rd, Leiden, ESCOM Sci. Publ., 1995, pp. 40-41. 221. Motawia,M.S., Meldal,M., Sofan,M., Stein,P., and Pedersen,E.B., 2'-Deoxypyromycin. - Synthesis and antiviral evaluation, Synthesis, (1995) 265-270. 222. Paulsen,H., Peters,S., Bielfeldt,T., Meldal,M., and Bock,K., Synthesis of the glycosyl amino acids N-Fmoc-Ser(Ac4--D-Galp-(1 - 3)- Ac2--D-Ga1N3p)-OPfp and N-Fmoc-Thr(Ac4--D-Gal p-(1 - 3)- Ac2--D-Ga1N3p)-OPfp and the application in the solidphase peptide synthesis of multiply glycosylated mucin peptides with Tn and T antigenic structures, Carbohydr. Res., 268 (1995) 17-34. 223. Peters,S., Lowary,T.L., Hindsgaul,O., Meldal,M., and Bock,K., Solid-phase synthesis of a fucosylated glycopeptide of human factor IX with a fucose--(1-O)-serine linkage, J. Chem. Soc. , Perkin Trans. 1, (1995) 3017-3022. 224. Renil,M. and Meldal,M., Synthesis and application of a PEGA polymeric support for high capacity continuous flow solid-phase peptide synthesis, Tetrahedron Lett., 36 (1995) 4647-4650. 225. Rio-Anneheim,S., Paulsen,H., Meldal,M., and Bock,K., Synthesis of the building blocks N-Fmoc-O-[-D- Ac3GalN3p-(1-3)- -D-Ac2GalN3p]-Thr-OPfp and N-Fmoc-O-[-D-Ac3GalN3p-(1-6)--D- Ac2GalN3p]-Thr-OPfp and their application in the solid phase glycopeptide synthesis of core 5 and core 7 mucin O-glycopeptides, J. Chem. Soc. , Perkin Trans. 1, (1995) 1071-1080. 226. Rønnow,T.E.C.L., Meldal,M., and Bock,K., Synthesis of unsymmetrical trehalose analogues by silver trifluoromethanesulphonate promoted glycosylations, J. Carbohydr. Chem., 14 (1995) 197-211. 227. Bock,K., Stuike-Prill,R., and Meldal,M., Conformational assessment of glycopeptides. In: Bock,K., Clausen,H. (Eds.), Complex carbohydrates in drug research. Structural and functional aspects, Copenhagen, Munksgaard, 1994, pp. 229-242. 228. Bundle,D.R., Eichler,E., Gidney,M.A.J., Meldal,M., Ragauskas,A., Sigurskjold,B.W., Sinnot,B., Watson,D. , Yaguchi,M., and Young,N.M., Molecular recognition of a Salmonella trisaccharide epitope by monoclonal antibody Se155-4, Biochemistry, 33 (1994) 5172-5182. 229. Christensen,M., Meldal,M., and Bock,K., Synthesis of glycopeptides containing 6'-O-Phosphorylated disaccharides as ligands for the mannose 6-phosphate receptors. In: Hodges,R.S., Smith,J.A. (Eds.), Peptides 1993. Proc. Am. Pept. Symp., 13'th, Leiden, ESCOM Sci.Publ., 1994, pp. 332-334. 230. Christensen,M.K., Meldal,M., Bock,K., Cordes,H., Mouritsen,S., and Elsner,H., Synthesis of glycosylated peptide templates containing 6'-O- phosphorylated mannose disaccharides and their binding to the mannose-6-phosphate receptor, J. Chem. Soc. , Perkin Trans. 1, (1994) 1299-1310. 231. Christiansen-Brams,I., Jansson,A.M., Meldal,M., Breddam,K., and Bock,K., Silyl protection in the solid-phase synthesis of N-linked glycopeptides. Preparation of glycosylated fluorogenic substrates for subtilisins, Bioorg. Med. Chem., 2 (1994) 1153-1167. 232. Ferro,V., Meldal,M., and Bock,K., Synthesis of 2'- and 2''-O-acylated maltotriosides as potential fluorescence-quenched substrates for -amylase, J. Chem. Soc. , Perkin Trans. 1, (1994) 2169-2176. 233. Granovsky,M., Bielfeldt,T., Peters,S., Paulsen,H., Meldal,M., Brockhausen,J., and Brockhausen,I., UDP-Gal: glycoprotein-N-acetyl-D-galactosamine -3-D-galactosyltransferase activity synthesizing O-glycan Core 1 is controlled by the amino acid sequence and glycosylation of glycopeptide substrates, Eur. J. Biochem., 221 (1994) 1039-1046. 234. Jansson,A.M., Meldal,M., and Bock,K., N-Fmoc-8-amino-2,8-dideoxy--KDO pentafluorophenyl ester used as a building block in multiple column solid phase neoglycopeptide synthesis. In: Epton,R. (Ed.), Innovation Perspectives in Solid Phase Synthesis, Leiden, ESCOM Sci. Publ., 1994, pp. 559-562. 235. Meinjohanns,E., Meldal,M., and Bock,K., Application of the dithiasuccinoyl-(Dts) amino protecting group in solid phase synthesis of O--GlcNac peptides and in stereoselective synthesis of 2-amino-2-deoxy-glucopyranosides, Abstr. XVII'th International Carbohydrate Symposium, Ottawa, 1994., (1994) 260. 236. Meldal,M., Svendsen,I., Breddam,K., and Auzanneau,F.-I., Portion-mixing peptide libraries of quenched fluorogenic substrates for complete subsite mapping of endoprotease specificity, Proc. Natl. Acad. Sci., 91 (1994) 3314-3318. 237. Meldal,M., Recent development in glycopeptide and oligosaccharide synthesis, Curr. Opin. Struct. Biol., 4 (1994) 710-718. 238. Meldal,M., Christiansen-Brams,I., Christensen,M.K., Mouritsen,S., and Bock,K., Synthesis and biological application of glycosylated peptide templates. In: Bock,K., Clausen,H. (Eds.), Complex carbohydrates in drug research. Structural and functional aspects, Copenhagen, Munksgaard, 1994, pp. 153-165. 239. Meldal,M., Bielfeldt,T., Peters,S., Jensen,K.J., Paulsen,H., and Bock,K., Susceptibility of glycans to -elimination in Fmoc- based O-glycopeptide synthesis, Int. J. Peptide Protein Res., 43 (1994) 529-536. 240. Meldal,M. and Bock,K., A general approach to the synthesis of O- and N-linked glycopeptides, Glycoconjugate J., 11 (1994) 59-63. 241. Meldal,M., Auzanneau,F.-I., Hindsgaul,O., and Palcic,M.M., A PEGA resin for use in solid phase chemical/enzymatic synthesis of glycopeptides, J. Chem. Soc. , Chem. Commun., (1994) 1849-1850. 242. Meldal,M., Auzanneau,F.-I., and Bock,K., PEGA, Characterization and application of a new type of resin for peptide and glycopeptide synthesis. In: Epton,R. (Ed.), Innovation and Perspectives in Solid Pphase Synthesis, Mayflower Worldwide Limited, Kingswinford, 1994, pp. 259-266. 243. Meldal,M., Multiple column synthesis of quenched solid-phase bound fluorogenic substrates for characterization of endoprotease specificity, Methods: A Companion to Methods in Enzymology, 6 (1994) 417-424. 244. Meldal,M., Glycopeptide synthesis. In: Lee,Y.C., Lee,R.T. (Eds.), Neoglycoconjugates: preparation and application, San Diego, Academic Press, 1994, pp. 145-198. 245. Mouritsen,S., Meldal,M., Christiansen-Brams,I., Elsner,H., and Werdelin,O., Attachment of oligosaccharides to peptide Ag profoundly affects binding to MHC class II molecules and peptide immunogenicity, Eur. J. Immunol., 24 (1994) 1066-1072. 246. Paulsen,H., Bielfeldt,T., Peters,S., Meldal,M., and Bock,K., A new strategy for the solid-phase synthesis of O-glycopeptides via 2-azido-glycopeptides, Liebigs Ann., (1994) 369-379. 247. Paulsen,H., Bielfeldt,T., Peters,S., Meldal,M., and Bock,K., Application of the azido glycopeptide synthesis strategy for the multiple column solid phase synthesis of mucin O-glycopeptides, Liebigs Ann., (1994) 381-387. 248. Rønnow,T.E.C.L., Meldal,M., and Bock,K., The use of O-glycosyl trichloroacetimidates in the synthesis of unsymmetrical trehalose analogues, Tetrahedron Assym., 5 (1994) 2109-2122. 249. Rønnow,T.E.C.L., Meldal,M., and Bock,K., Gram-scale synthesis of ,-trehalose 6-monophosphate and ,-thrhalose 6,6'-diphosphate, Carbohydr. Res., 260 (1994) 323-328. 250. Vargas-Berenguel,A., Meldal,M., Paulsen,H., and Bock,K., Convenient synthesis of O-(2-Acetamido-2-deoxy--D- glucopyranosyl)-serine and - threonine building blocks for solid- phase glycopeptide assembly, J. Chem. Soc. , Perkin Trans. 1, (1994) 2615-2619. 251. Vargas-Berenguel,A., Meldal,M., Paulsen,H., Jensen,K.J., and Bock,K., Synthesis of glycosyltyrosine building blocks for solid-phase glycopeptide assembly: use of aryl tert-butyl ethers as glycosyl acceptors in aromatic glycosylations, J. Chem. Soc. , Perkin Trans. 1, (1994) 3287-3294. 252. Christensen,M.K., Meldal,M., and Bock,K., Synthesis of mannose 6-phosphate-containing disaccharide threonine building blocks and their use in solid-phase glycopeptide synthesis, J. Chem. Soc. , Perkin Trans. 1, (1993) 1453-1460. 253. Christiansen-Brams,I., Meldal,M., and Bock,K., Silyl protection in the solid-phase synthesis of N-linked Neoglycopeptides. One step deprotection of fully protected neoglycopeptides, Tetrahedron Lett., 34 (1993) 3315-3318. 254. Christiansen-Brams,I., Meldal,M., and Bock,K., Protected-mode synthesis of N-linked glycopeptides - single-step preparation of building blocks as peracetyl glycosylated N--Fmoc asparagine OPfp esters, J. Chem. Soc. , Perkin Trans. 1, (1993) 1461-1471. 255. Christiansen-Brams,I., Meldal,M., and Bock,K., Solid phase synthesis of a di-N-glycosylated RGD analog. In: Schneider,C.H., Eberle,A.N. (Eds.), Peptides 1992, Proc. Eur. Pept. Symp., 22'nd, Leiden, ESCOM, 1993, pp. 365-366. 256. Jensen,K.J., Meldal,M., and Bock,K., Glycosylation of phenols. Preparation of 1,2-cis and 1,2-trans glycosylated tyrosine derivatives to be used in solid-phase glycopeptide synthesis, J. Chem. Soc. , Perkin Trans. 1, (1993) 2119-2129. 257. Meldal,M., Holm,C.B., Bojesen,G., Jacobsen,M.H., and Holm,A., Multiple column peptide synthesis, Part 2(1,2), Int. J. Peptide Protein Res., 41 (1993) 250-260. 258. Meldal,M., Multiple column peptide synthesis, development and application. In: Schneider,C.H., Eberle,A.N. (Eds.), Peptides 1992, Proc. Eur. Pept. Symp., ESCOM, Leiden, 1993, pp. 61-62. 259. Meldal,M., Mouritsen,S., and Bock,K., Synthesis and immunological properties of glycopeptide T-cell determinants. In: Garegg,P.J., Lindberg,A.A. (Eds.), Carbohydrate Antigens, A. C. S. Symp. Ser. 519, New York, Academic Press, 1993, pp. 19-33. 260. Muldbjerg,M., Meldal,M., Breddam,K., and Sigsgaard,P., Protease activity in beer and correlation to foam. In: European Brewing Convention, Proc.24'th Congress, Oxford, Oxford University Press, 1993, pp. 357-364. 261. Reimer,K., Meldal,M., Fukase,K., Kusumoto,S., and Bock,K., Small scale solid-phase O-glycopeptide synthesis of linear and cyclized hexapeptides from blood clotting factor IX containing O- (-D-Xyl-1-3--D-Xyl-1-3--D-Glc)-L-Ser, J. Chem. Soc. , Perkin Trans. 1, (1993) 925-932. 262. Sørensen,S.B., Bech,L.M., Meldal,M., and Breddam,K., Mutational replacements of amino acid residues forming the hydrophobic S4 binding pocket of subtilisin 309 from Bacillus lentus, Biochemistry, 32 (1993) 8994-8999. 263. Bielfeldt,T., Peters,S., Meldal,M., Bock,K., and Paulsen,H., A New Strategy for Solid-Phase Synthesis of O-Glycopeptides, Angew. Chem. Int. Ed. Engl., 31 (1992) 857-859. 264. Breddam,K. and Meldal,M., Substrate preferences of glutamic-acid-specific endopeptidases assessed by peptide substrates based on intramolecular fluorescence quenching, Eur. J. Biochem., 206 (1992) 103-107. 265. Christiansen-Brams,I., Meldal,M., and Bock,K., Synthesis of the 1-amino-alditols derived from cellobiose, lactose and maltose. A comprehensive NMR study of some alditols and amino-alditols, J. Carbohydr. Chem., 11 (1992) 813-835. 266. Grøn,H., Meldal,M., and Breddam,K., Extensive comparison of substrate preferences of two subtilisins as determined with peptide substrates which are based on the principle of intramolecular quenching, Biochemistry, 31 (1992) 6011-6018. 267. Jansson,A.M., Meldal,M., and Bock,K., Solid-phase synthesis and characterization of O-dimannosylated heptadecapeptide analogues of human insulin-like growth factor 1 (IGF-1), J. Chem. Soc. , Perkin Trans. 1, (1992) 1699-1707. 268. Jensen,K.J., Meldal,M., and Bock,K., Glycosylation of tyrosine derivatives and their application for solid phase synthesis. In: Smith,J.A., Rivier,J.E. (Eds.), Peptides 1991, Proc. Am. Pept. Symp., 12'th, Leiden, Pierce Chemical Company, 1992, pp. 587-588. 271. Meldal,M., PEGA: A flow stable polyethylene glycol dimethyl acrylamide copolymer for solid phase synthesis, Tetrahedron Lett., 33 (1992) 3077-3080. 272. Meldal,M., Jensen,K.J., Jansson,A.M., and Bock,K., Active esters in solid phase glycopeptide synthesis: A general approach. In: Epton,R. (Ed.), Innovation and Perspectives in Solid Phase Synthesis 1992, pp. 179-184. 273. Meldal,M., Christensen,M.K., and Bock,K., Large scale synthesis of D-mannose 6-phosphate and other hexose 6-phosphates, Carbohydr. Res., 235 (1992) 115-127. 274. Mouritsen,S., Meldal,M., Werdelin,O., Hansen,A.S., and Buus,S., MHC molecules protect T cell epitopes against proteolytic destruction, J. Immunol., 149 (1992) 1987-1993. 275. Paul,S., Sun,M., Mody,R., Tewary,H.K., Stemmer,P., Massey,R.J., Gianferrara,T., Mehrotra,S., Dreyer,T., Meldal,M., and Tramontano,A., Peptidolytic monoclonal antibody elicited by a neuropeptide, J. Biol. Chem., 267 (1992) 13142-13145. 276. Peters,S., Bielfeldt,T., Meldal,M., Bock,K., and Paulsen,H., Multiple-column solid-phase glycopeptide synthesis, J. Chem. Soc. , Perkin Trans. 1, (1992) 1163-1171. 277. Peters,S., Bielfeldt,T., Meldal,M., Bock,K., and Paulsen,H., Solid phase peptide synthesis of mucin glycopeptides, Tetrahedron Lett., 33 (1992) 6445-6448. 278. Szwajcer-Dey,E., Rasmussen,J., Meldal,M., and Breddam,K., Proline-specific Endopeptidases from microbial sources: Isolation of an enzyme from a Xanthomonas sp, J. Bacteriology, 174 (1992) 2454-2459. 279. Bock,K., Refn,S., and Meldal,M., Controlled reduction of acarbose: Conformational analysis of acarbose and the resulting saturated products, Carbohydr. Res., 221 (1991) 1-16. 280. Breddam,K., Widmer,F., and Meldal,M., Amidation of growth hormone releasing factor (1-29) by serine carboxypeptidase catalysed transpeptidation, Int. J. Peptide Protein Res., 37 (1991) 153-160. 281. Jacobsen,M.H., Buchardt,O., Holm,A., and Meldal,M., New self indicating active esters for solid phase peptide synthesis. In: Giralt,E., Andreu,D. (Eds.), Peptides 1990, Proc. Eur. Pept. Symp., 21'th, ESCOM Sci. Publ., Leiden, 1991, pp. 192-193. 282. Meldal,M., Solid phase synthesis of internally quenched protease substrates. In: Giralt,E., Andreu,D. (Eds.), Peptides 1990. Proc. Eur. Pept. Symp., 22'nd, Leiden, ESCOM Sci. Publ., 1991, pp. 208-209. 283. Meldal,M. and Breddam,K., Anthranilamide and nitrotyrosine as a donor acceptor pair in internally quenched fluorescent substrates for endopeptidases - Multicolumn peptide synthesis of enzyme substrates for subtilisin carlsberg and pepsin, Anal. Biochem., 195 (1991) 141-147. 284. Mouritsen,S., Meldal,M., Ruud-Hansen,J., and Verdelin,O., T-helper-cell determinants in protein antigens are preferentially located in cysteine rich antigen segments resistant to proteolytic cleavage by cathepsin B, L and D, Scand. J. Immunol., 34 (1991) 421-431. 285. Peters,S., Bielfeldt,T., Meldal,M., Bock,K., and Paulsen,H., Multiple column solid phase glycopeptide synthesis, Tetrahedron Lett., 32 (1991) 5067-5070. 286. Jakobsen,M.H., Buchardt,O., Holm,A., and Meldal,M., A facile one-pot synthesis of 3,4-dihydro-3-hydroxy-4-oxo-1,2,3- benzotriazine and derivatives, Synthesis, (1990) 1108-1010. 287. Jansson,A.M., Meldal,M., and Bock,K., The active ester N-Fmoc-3-O-[Ac4--D-Manp-(1.fwdarw.2)-Ac3- -D- Manp-1-]-threonine-O-Pfp as a building block in solid- phase synthesis of an O-linked dimannosyl glycopeptide, Tetrahedron Lett., 31 (1990) 6991-6994. 288. Meldal,M. and Bock,K., Pentafluorophenyl esters for temporary carboxyl group protection in solid phase synthesis of N-linked glycopeptides, Tetrahedron Lett., 31 (1990) 6987-6990. 289. Meldal,M. and Breddam,K., Multi column synthesis of protease substrates, Innov. Perspec. SPS, 1 (1990) 533-536. 290. Meldal,M., Syntetiske peptider og oligosaccharider som ideelle modelstoffer i biologiske systemer, Dansk Kemi, (1990) 125-130. 291. Meldal,M. and Jensen,K.J., Pentafluorophenyl esters for the temporary protection of the - carboxy group in solid phase glycopeptide synthesis, J. Chem. Soc. , Chem. Commun., (1990) 483-485. 292. Suenson,E., Bjerrum,P., Holm,A., Lind,B., Meldal,M., Selmer,J., and Petersen,L.C., The role of fragment X polymers in the fibrin enhancement of tissue-plasminogen activator-catalyzed plasmin formation, J. Biol. Chem., 265 (1990) 22228-22237. 293. Buchardt,O., Karup,G., Egholm,M., Koch,T., Henriksen,U., Meldal,M., Jeppesen,C., and Nielsen,P.E., Photonucleases. In: Nielsen,P.E. (Ed.), Photochemical Probes in Biochemistry Kluwer Academic Publishers, 1989, pp. 209-218. 294. Holm,A. and Meldal,M., Multiple Column Peptide Synthesis. In: Jung,G., Bayer,E. (Eds.), Peptides 1988, Proc. Eur. Pept. Symp., 20'th, Berlin, Walter de Gruyter, 1989, pp. 208-210. 295. Mouritsen,S., Meldal,M., Rubin,B., Holm,A., and Werdelin,O., The T-lymphocyte proliferative response to synthetic peptide antigens of defined secondary structure, Scand. J. Immunol., 30 (1989) 723-730. 296. Atherton,E., Jill,L.H., Meldal,M., Sheppard,R.C., and Valerio,R.M., Peptide synthesis. Part 12. 3,4-Dihydro-4-oxo-1,2,3-benzotriazin- 3-yl esters of fluorenylmethoxycarbonyl amino acids as self- indicating reagents for solid phase peptide synthesis, J. Chem. Soc. , Perkin Trans. 1, (1988) 2887-2894. 297. Cameron,L.R., Holder,J.L., Meldal,M., and Sheppard,R.C., Peptide synthesis. Part 13. Feedback control in solid phase synthesis. Use of fluorenylmethoxycarbonyl amino acid 3,4-dihydro- 4-oxo-1,2,3-benzotriazin-3-yl esters in a fully automated system, J. Chem. Soc. , Perkin Trans. 1, (1988) 2895-2901. 298. Karup,G., Meldal,M., Nielsen,P.E., and Buchardt,O., 9-Acridinyl peptides and 9-acridinyl-4-nitrophenylsulfonyl peptides. Synthesis, binding to DNA, and photoinduced DNA cleavage, Int. J. Peptide Protein Res., 32 (1988) 331-343. 299. Cameron,L., Meldal,M., and Sheppard,R.C., Feedback control in organic synthesis. A system for solid phase peptide synthesis with true automation, J. Chem. Soc. , Chem. Commun. , (1987) 270-272. 300. Krogfelt,K.A., Meldal,M., and Klemm,P., K88 fimbrial antigens: identification of antigenic determinants by the use of synthetic peptides, Microb. Pathog., 2 (1987) 465-472. 301. Meldal,M. and Sheppard,R.C., Esters of Fmoc amino acids with 3,4-dihydro-3-hydroxy-4-oxo-1,2, 3- benzotriazine. A new class of self-indicating, activated intermediates for solid phase synthesis. In: Theodoropoulos,D. (Ed.), Peptides 1986, Proc. Eur. Pept. Symp., Berlin, Walter de Gruyter, 1987, pp. 131-134. 302. Atherton,E., Cameron,L., Meldal,M., and Sheppard,R.C., Self-indicating activated esters for use in solid phase peptide synthesis. Fluorenylmethoxycarbonyl amino acid derivatives of 3- hydroxy-4-oxodihydrobenzotriazine, J. Chem. Soc. , Chem. Commun., (1986) 1763-1765. 303. Meldal,M., Synthesis of a putative antigenic heptapeptide from Escherichia coli K88 ab protein fimbriae, Acta Chem. Scand., B40 (1986) 250-256. 304. Meldal,M., Synthesis of a putative subtype specific antigenic heptapeptide from escherichia coli K88 ad protein fimbriae, Acta Chem. Scand., B 40 (1986) 242-249. 305. Meldal,M. and Kindtler,J.W., Synthesis of a proposed antigenic hexapeptide from Escherichia coli K88 protein fimbriae, Acta Chem. Scand., B40 (1986) 235-241. 306. Meldal,M., Conformation of small peptides in solution, determined by NMR spectroscopy and computer simulation. In: Lark,D.L. (Ed.), Protein-carbohydrate interactions in biological systems, Academic Press, London, 1986, pp. 297-299. 307. Norberg,T., Svenson,S.B., Bock,K., and Meldal,M., Immunochemistry of Salmonella O-antigens: studies of Salmonella BO antigen epitopes by enzyme-linked immunosorbent inhibition assays, FEMS Microbiol. Lett., 28 (1985) 171-176. 308. Bock,K. and Meldal,M., Synthesis of the branchpoint tetrasaccharide of the O-specific determinant of Salmonella serogroup B, Acta Chem. Scand., B38 (1984) 71-77. 309. Bock,K. and Meldal,M., Synthesis of tetrasaccharides related to the O-specific determinants of Salmonella serogroups A, B and D1, Acta Chem. Scand., B38 (1984) 255-266. 310. Bock,K., Meldal,M., Bundle,D.R., Iversen,T., Pinto,B.M., Garegg,P.J., Kvanstroem,I., Norberg,T., Lindberg,A.A., and Svenson,S.B., The conformation of Salmonella O-antigenic oligosaccharides of serogroups A, B, and D1 inferred from proton and carbon-13 nuclear magnetic resonance spectroscopy, Carbohydr. Res., 130 (1984) 35-53. 311. Bock,K., Meldal,M., Bundle,D.R., Iversen,T., Garegg,P.J., Norberg,T., Lindberg,A.A., and Svenson,S.B., The conformation of Salmonella O-antigenic polysaccharide chains of serogroups A, B, and D1 predicted by semi-empirical, hard- sphere (HSEA) calculations, Carbohydr. Res., 130 (1984) 23-34. 312. Bock,K. and Meldal,M., Mercury iodide as a catalyst in oligosaccharide synthesis, Acta Chem. Scand., B37 (1983) 775-783. 313. Bock,K., Meldal,M., Meyer,B., and Wiebe,L., Isomerization of D-glucose with glucose isomerase. A mechanistic study, Acta Chem. Scand., B37 (1983) 101-108. 314. Bock,K. and Meldal,M., Synthesis of disaccharides related to the O-specific polysaccharide of Salmonella typhimurium, Acta Chem. Scand., B37 (1983) 629-638. 315. Meldal,M., Syntese og konformationsanalyse af O-specifikke antigener med tilknytning til Salmonella serogruppe A,B og D1, Lyngby, Denmark, Ph.D. Thesis, D.T.H., 1983, 79 pp. 316. Bock,K., Meldal,M., and Meyer,B., En undersøgelse over glucoseisomerases virkningsmekanisme, D.T.H., Research sponsored by NOVO Industries A/S, Lyngby, Denmark, 1981, 60 pp. 317. Madsen,J.O., Meldal,M., Mortensen,S., and Olsson,B., A facile route to 2-substituted indoles, Acta Chem. Scand., B35 (1981) 77-81. 318. Meldal,M., Fremstilling af 3,6-dideoxy-hexoser og belysning af deres kemiske egenskaber og anvendelse, Lyngby, Denmark, Dissertation, D.T.H., 1980, 74 pp. Patent List 319. K. Breddam, M. Meldal, S. Aasmund-Olsen, and F. Widmer. Process for preparing derivatives of a growth hormone releasing factor and peptides being useful as intermediates in said process. Carlbiotech ltd a/s (dk). Anonymous. Denmark:WO9118998 (A1)EP0537185 (A1)IE911831 (A1)EP0537185 (A0)AU647796B (B2). CS19910001631 19910530(CS9101631), 1992. Abstract of corresponding document: WO9118998Derivatives of growth hormone releasing factor GRF(1-29)NH2 and analogs thereof, are prepared by reacting a substrate component of the formula GRF'-Met-Ser-X, wherein GRF' denominates the native GRF(1-26) sequence or analogs thereof including GRF(n-26) fragments, where n is from 1 to 8, and X is an acyclic alpha -amino carboxylic acid residue having an uncharged hydrophilic side chain of at least the size of a methyl group, preferably Ala, Thr, Ser, Asn or Gln, with H-Arg-NH2 as mucleophile component in the presence of an L-specific serine or thiolcarboxypeptidase enzyme from yeast or of animal, vegetable or other microbial origin, preferably CPD-Y from yeast, in an aqueous solution or dispersion having a pH of from 6 to 9, and if necessary coupling the desired N-terminal (1-(n-1)) fragment chemically or enzymatically. GRF-related peptides of the formula GRF"-Met-Ser-X, wherein GRF" denominates the native GRF(1-26) sequence, wherein from 1 to 4 amino acid residues may be replaced or deleted or the des- alpha -NH2 derivatives thereof, and X is as described above and useful intermediates. The process enables a selective transpeptidation leading to biologically active GRF-related amides in good yields. C07K14/60; C12N9/48; C07K14/435; C12N9/48; (IPC1-7): C12P21/02. 320. J. Buchardt, N. Foged, M. Meldal, J.-M. Delaisse, M. Engsig, M. Ferreras, M. Karsdal, M. d. C. Ovejero, C. B. Schiødt, and B. Winding. Substituted phosphinate based peptide derivatives. OSTEOPRO A/S. Anonymous. EP0276436 WO0043404 WO9903878 XP002165429 XP002165430 XP000992863 XP002165431 XP002165432 XP002165433 XP000566937 XP002165434. WO2000EP09173 20000919(WO0125264; GB9922577.3; WO0125264 (A3) WO0125264 (A3) EP1220871 (A3) EP1220871 (A3) EP1220871 (A2) EP1220871 (A0)), 2001. Abstract of WO0125264: Compounds of Formula (I) are proposed for use in the treatment of metabolic bone diseases such as osteoporosis and bone metastasis. In the formulas wherein R<1> is 1. a hydrogen atom, 2. an amino-protecting group, 3. an alkyl, alkenyl, alkynyl or aryl group, 4. a group R<1b>-NH-CR<1c>R<1d>-CO- in which 4.1. R<1b> is 4.1.1. a hydrogen atom, 4.1.2. a natural or unnatural alpha -amino acid, or a peptide consisting of the same, 4.1.3. an alkyl, alkenyl, alkynyl or aryl group, 4.2. R<1c> and R<1d> independently of each other are 4.2.1. a hydrogen atom, 4.2.2. a radical corresponding to a side chain of a natural or non-natural alpha -amino acid, 4.2.3. an alkyl, alkenyl, alkynyl or aryl group, 5. a group R<1e>-CO- in which R<1e> is 5.1. a hydrogen atom, 5.2. an alkyl, alkenyl, alkynyl or aryl group, 6. a group of R<1f>-SO2- in which R<1f> is an alkyl, alkenyl, alkynyl or aryl group. R<2>, R<3>, R<4> and R<8> independently of each other are 1. a group as defined for R<1c>, 2. a group R<2a>-CH2- in which R<2a> is 2.1. an aryl group, 2.3. a heteroalicylic or heteroaromatic group. R<5> is 1. a hydrogen atom, or 2. an alkyl, alkenyl, alkynyl or aryl group. R<6> and R<7> independently of each other are 1. a hydrogen atom, or 2. an alkyl group. R<9> is 1. a group R<3a>-X<c>- in which 1.1. R<3a> is 1.1.3., an alkyl, alkenyl, alkynyl or aryl group, 1.1.4. a heteroalicylic or heteroaromatic group 1.1.3. a group as defined for R<2>, 1.2. X<c> is O, S or NH. X<a> and X are: O, S or NH. C07K5/10; C07K7/02; C07K7/06; A61K38/00; C07K5/00; C07K7/00; A61K38/00; (IPC1-7): C07K7/00 -. European:C07K5/10P; C07K7/02; C07K7/06A. 321. S. F. Christensen, I. Johannsen, J. M. Carstensen, L. Kuhlmann, and M. Meldal. Identification of encoded beads. VERSAMATRIX A/S. Anonymous. EP20040803061 20041222(EP1701784 WO2005061094 (A1) EP1701784 (A0)), 2006. WO2005061094 The present invention is relates to methods for the identification of spatially encoded beaded or granulated matrices comprising a plurality of immobilised particles. The identification is based on a distance matrix determination or based on a set of geometrical figures, such a triangles, on the basis of which individual matrices can be determined. B01J19/00; G01N15/06; G01N15/14; G01N21/64; G06K9/64; B01J19/00; G01N15/06; G01N15/14; G01N21/64; G06K9/64. European:B01J19/00C; G01N21/64P; G06K9/64A2F. 322. S. F. Christensen, J. H. Truelsen, M. Meldal, R. Michael, and I. Johannsen. Spatially encoded polymer matrix. Carlsberg A/S. Anonymous. US:WO2003DK00635 20030926; US20050529397 20050328(US2006127369), 2006. Abstract of US2006127369: The invention relates to a spatially encoded polymer matrix in the form of a bead or a granule for combinatorial solid phase synthesis, assaying, functional proteomics and diagnostic use. Compositions of such beads or granules are also provided. Each beaded polymer matrix of the composition comprises a plurality of spatially immobilised particles. The spatial immobilisation of the particles confers on each beaded polymer matrix a "fingerprint" which enables identification of unique beads in a population of beads. The unique identification of individual beads makes it possible to perform combinatorial chemistry strategies while logging individual chemical transformation. Also provided are methods for detection of relative positions in space of particles, methods for generating matrices, methods for distance matrix determination, methods for identifying individual matrices and devices for recording and storing images of matrices. A01N63/00; A01N63/00. 323. N. Foged, J.-M. Delaisse, and M. Meldal. The use of proteinase inhibitors for prevention or reduction of bone resorption. CT FOR CLINICAL & BASIC RES. Anonymous. EP0611756 EP0685557 XP002049983 XP002049984 XP002049985 XP002049986 XP002049988 XP002049987 XP000578393. WO1997EP04110 19970729; AU20010057699D 20010727(WO9804287; AU5769901; EP0915709 (A1)EP0915709 (A0)AU733104B (B2)), 2007. Abstract of WO9804287: Bone metabolic disease is treated by inhibition of the production or action of membrane-type matrix metalloproteinase (MT-MMP) or the matrix metalloproteinase 12 (MMP-12) involved in the resorptive activity of osteoclasts. Inhibitors for MT-MMP and MMP-12 and membrane-associated metalloproteinase activity include peptides and analogues of peptides generated using a PEGA bead library, antisense nucleic acid agents and antibodies. The proteinases MT1-MMP and MMP-12 are found to be expressed in osteoclasts and may be selectively inhibited. A61K38/57; A61K39/395; A61K48/00; A61P19/08; A61K38/55; A61K39/395; A61K48/00; A61P19/00; (IPC1-7): A61K48/00; A61K38/57; A61K39/395; A61P19/08 A61K45/00; A61P19/10; C07K1/04; C07K14/81; C07K16/40; A61K45/00; C07K1/00; C07K14/81; C07K16/40; (IPC1-7): A61K39/395; C07K7/04; C07K14/81; C12N15/52. European:C07K1/04C; C07K14/81B4; C07K16/40. 324. G. Hagel, O. Thastrup, M. Meldal, J. C. Norrild, and M. Hentzer. Identification of compounds modifying a cellular response. Carlsberg A/S. Anonymous. Denmark:US5510240; WO03038431; US2004096906; WO2005045430; XP002345203; XP002345206; XP002345232; XP001041521XP; 002231929XP; 002345461. WO2005DK00347 20050525; PCT/DK2005/000347(WO2005116656; WO2005116643 (A3)WO2005116643 (A2)EP1761783 (A3)EP1761783 (A2)EP1759212 (A1)EP1761783 (A0)EP1759212 (A0)CA2568168 (A1)AU2005248453 (A1)), 2006. Abstract of WO2005116656: The present invention relates to methods for identifying compounds capable of modulating a cellular response. The methods involve attaching living cells to solid supports comprising a library of test compounds. The test compounds are linked to the solid support via cleavable linkers and may thus be released from the solid supports. Solid supports comprising cells, wherein the cellular response of interest has been modulated are selected and the test compound of the solid support can then be identified. The cellular response may for example be changes in complex formation between proteins. C07K1/04; C07K5/00; C07K5/103; C07K7/00; C07K7/06; C07K7/08; G01N33/50; G01N33/543; G01N33/68; G01N35/00; C07K1/00; C07K5/00; C07K7/00; G01N33/50; G01N33/543; G01N33/68; G01N35/00; (IPC1-7): G01N33/68; G01N33/543. European:C07K1/04C; C07K5/10A1A; C07K7/06A; C07K7/06B; C07K7/08A; C07K7/08B; G01N33/50D2E2; G01N33/543D; G01N33/68A10. 325. Holm, M. Meldal, and O. Buchardt. A method and an apparatus for dissolving a solid substance in a solvent. Anonymous. Anonymous. WO1990DK00015 19900117(WO9007975), 1990. Abstract of WO9007975 A method for dissolving a solid substance in a solvent comprises the steps of: arranging the solid substance (11) within a chamber defined in a substance-receiving body (10); establishing a closed fluid-flow circuit (18) partly defined by said chamber; and circulating the solvent in said circuit so as to at least partly dissolve the solid substance (11) in the solvent. The apparatus for performing the method comprises: a body (10) defining a chamber for receiving the solid substance (11) therein; fluid-flow circuit means; connecting means (12, 13) for connecting said circuit means to said body (10), so as to form a closed fluid-flow circuit (18) partly defined by said chamber; and means (20) for circulating the solvent in the fluid-flow circuit. The method and apparatus described are advantageously applicable for performing a fully automated peptide synthesis. B01F1/00; B01F5/10; B01J19/00; C40B60/14; B01F1/00; B01F5/00; B01J19/00; C40B60/14; (IPC1-7): B01F1/00. class- EU: B01F1/00F; B01F5/10; B01J19/00C. 326. M. Meldal, A. Holm, and O. Buchardt. An apparatus and a method for the synthesis of peptides. Anonymous. Anonymous. Cited documents:WO8702138WO8203690WO8602168WO8706008EP0156588. WO1989DK00206 19890904(WO9002605), 1990. Abstract of WO9002605 An apparatus for use in chemical synthesis, especially peptide synthesis, comprises a synthesis chamber unit having a multiplicity of synthesis chambers, each of which has a liquid inlet and a liquid outlet, means for introducing liquid into the individual synthesis chambers and means for simultaneous removal of liquid via the liquid outlets of the synthesis chambers by regulation of the fluid pressure difference between the liquid inlets and the liquid outlets. A method for peptide synthesis using such an apparatus comprises the provision in each of the synthesis chambers of a solid-phase support material having a first, at least N-protected amino acid coupled thereto, after which a liquid deprotection reagent is introduced into the synthesis chambers. Following deprotection, the deprotection reagent is removed, after which a second, at least N-protected amino acid is introduced into each synthesis chamber in order to couple the first and second amino acids. Third, fourth, etc. amino acids may be coupled analogously. Complete removal of the deprotection reagent from the synthesis chambers and the support material can be ensured by incorporating a stable, intensely coloured dye, e.g., azorubin, in the deprotection reagent. The apparatus and the method make possible the parallel synthesis of a large number of peptides, e.g. peptides having overlapping amino acid sequences and constituting part of a longer peptide chain. The apparatus can be adapted to manual, semi-automatic or fully automatic performance of the various steps in the synthesis procedure. B01J19/00; C40B40/10; C40B60/14; B01J19/00; C40B40/04; C40B60/14; (IPC1-7): B01J19/00; C07K17/00; G01N33/543. European:B01J19/00C. 327. M. Meldal and K. Breddam. Fluorogenic peptides and their use in determination of enzymatic activities. Carlsberg A/S. Anonymous. World:EP19910908699 19910416; 0939/90; PTC 2900144(WO1991DK00102 19910416; DK19900000939 19900417; EP0528854; WO9116336 (A1)EP0528854 (A0)EP0528854 (B1)AU634395B (B2)):1-33, 1993. Abstract of corresponding document: WO9116336 A fluorogenic peptide exhibiting intramolecular quenching having the general formula F-A-Q-Y1 or Y2-Q-A-F wherein Q is a fluorescence quenching substituted amino acid residue (I) wherein R1, R2, R3, R4 and R5 are independently selected from hydrogen, hydroxy, alkyl, alkoxy, amino, nitro, amido, halogen, aryl or aralkyl, with the proviso that at least one of R1 to R5 is hydroxy and at least one is nitro, wherein X is a spacing group which may be absent or selected from any combination of -CO-NH-, -CO-O-, -S-, -S-S-, -O-, -NH- or -C6H4-, and n and m are integers from 0 to 10, F is a fluorescent group having a maximum emission within the absorption band for the quenching residue Q, A is a spacing entity selected from amino acid residues and peptide residues and may include a non-peptide molecular entity, e.g. a mono- or oligosaccharie being linked to the fluorescent group F via an amide bond or ester bond, Y1 is OH, NH2, an amino acid residue, a peptide residue which is preferably attachable to a solid phase or a C-terminal protective group, Y2 is H, an amino acid residue, a peptide residue or an N-terminal protective group. Preferred peptides are those, wherein Q is 3-nitro-tyrosine, i.e. F1-A1-Tyr(NO2)-Y1 wherein F1 is a fluorescent group having a maximum emission of from 400 to 460 nm, preferably anthraniloyl, A1 is an amino acid residue or a peptide residue, preferably having 2 to 15 amino acids, and linked to the group F via a peptide bond, and Y1 is as defined above. The peptides are useful as substrates for determination of enzymatic activities in a sample, e.g. biological systems by incubating with the sample under conditions favourable to enzymatic activities, and determining and comparing the fluorescence emitted before and after the incubation. The peptides may advantageously be prepared by parallel multi-column solid phase synthesis. C07K5/10; C07K5/107; C07K7/06; C07K7/08; C12Q1/37; C07K5/00; C07K7/00; C12Q1/37; (IPC1-7): C07K5/00; C07K7/00; C12Q1/37. C07K5/10A2; C07K7/06A; C12Q1/37. Patent. 328. M. Meldal. Poly(ethylene or propylene glycol)-containing polymer. Carlsberg A/S. Anonymous. Denmark:WO 93 16,118, A1 930819; US19930075758 19930611(US5352756; WO9316118 (A1) EP0625996 (A1) EP0625996 (A0) EP0625996 (B1) CA2129442 (C) AU660534B (B2)):1-30, 1994. Report a data error here Abstract of US5352756A crosslinked poly(ethylene or propylene)glycol-containing polymer which has a unique spatial structure and can be designed especially for application as a chromatographic resin or as a solid support for the synthesis of peptides, oligonucleotides or oligosaccharides or as a substrate for the immobilization of proteins. The polymer is formed by radical copolymerization of derivatized poly(ethylene or propylene) glycol bis-end substituted with a moiety selected from the group consisting of acryloylalkyl, acryloylaryl, acrylamidoalkyl and acrylamidoaryl with an acrylic amide, nitrile or ester. When it is to be used as a solid support or immobilization substrate, the polymer will incorporate a spacer comprising functional groups for the attachment of peptides, proteins, nucleotides or saccharides such as those selected from the group consisting of amino, alkylamino, hydroxy, carboxyl, mercapto, sulfeno, sulfino, sulfo and derivatives thereof. C07H21/00; C07K1/04; C07K1/113; C07K1/16; C08F283/06; C08F290/06; C08G65/32; C07H21/00; C07K1/00; C08F283/00; C08F290/00; C08G65/00; (IPC1-7): C08G63/48; C08G63/12Cl. C08F283/06. European:C07H21/00C4; C07K1/04A; C08F290/06B. 329. M. Meldal, M. K. Christensen, and H. C. Rozarth. Carbohydrate-containing compounds which bind to carbohydrate binding receptors. Carlsberg A/S and Mouritsen & Elsner. Anonymous. EP0175290; US5124437; EP0296374. WO1994DK00432 19941116(WO9514036), 1995. Abstract of WO9514036: Carbohydrate-containing compounds which contain saccharides or derivatives thereof and which bind to carbohydrate binding receptors are useful in pharmaceutical products for treatment of inflammatory diseases and other diseases. C07K9/00; A61K38/00; C07K9/00; A61K38/00; (IPC1-7): C07K9/00; A61K38/14. European:C07K9/00D. 330. M. Meldal and T. Groth. Hydroxy and amine functionalised resin. Anonymous. Anonymous. US:US20010942079 20010828(US2003096918; US6828392 (B2)), 2003. Report a data error here Abstract of US2003096918A star-blocked polymeric material based on polyethylene glycol and having a uniform distribution of both hydroxy and amine functional groups throughout the polymeric material is described. The polymeric material, known as HYDRA (hydroxy and amine functionalised resin), is prepared by forming a polyimine compound by reacting an aldehyde and an amine. The polyimine is then reacted with a reducing agent to form a star-blocked polymeric material. HYDRA resins can be used, for example, as solid supports for organic synthesis, for enzymatic assays, for immobilization of biomolecules, for controlled release of drugs, and for chromatographic separations. C08G12/06; C08G16/02; C08G73/02; C08L61/20; C08L61/30; C08L61/32; C08G12/00; C08G16/00; C08G73/00; C08L61/00; (IPC1-7); C08G73/00; C08L61/30; C08L61/32. European:C08G12/06; C08G16/02B2C; C08G73/02L; C08L61/20; C08L61/30; C08L61/32. 331. M. Meldal, R. Michael, I. Johannsen, S. F. Christensen, and J. H. Truelsen. Spatially encoded polymer matrix. Carlsberg A/S. Anonymous. CA:CA20032539890 20030926; WO2003DK00635 20030926;(CA2539890; WO2004028682 (A3)WO2004028682 (A2)EP1545762 (A3)EP1545762 (A2)EP1545762 (A0) AU2003266932 (A1)), 2003. WO2004028682: The invention relates to a spatially encoded polymer matrix in the form of a bead or a granule for combinatorial solid phase synthesis, assaying, functional proteomics and diagnostic use. Compositions of such beads or granules are also provided. Each beaded polymer matrix of the composition comprises a plurality of spatially immobilised particles. The spatial immobilisation of the particles confers on each beaded polymer matrix a "fingerprint" which enables identification of unique beads in a population of beads. The unique identification of individual beads makes it possible to perform combinatorial chemistry strategies while logging individual chemical transformation. Also provided are methods for detection of relative positions in space of particles, methods for generating matrices, methods for distance matrix determination, methods for identifying individual matrices and devices for recording and storing images of matrices. B01J19/00; G01N15/14; G01N21/05; B01J19/00; G01N15/14; G01N21/03. European:B01J19/00C. 332. M. Meldal and M. Grøtli. Beaded polyethylene glycol-based resin. Carlsberg A/S. Anonymous. US:AU20020353380 20020709; PCT/IB2002/005542(AU2002353380; WO03025039 (A3)WO03025039 (A2)EP1425321 (A3)EP1425321 (A2)US6642334 (B2)):1-27, 2003. Abstract of corresponding document: WO03025039Described herein is a pentaalkyldisiloxane containing polymeric surfactant prepared by the copolymerization of an alkoxypolyoxyalkylenyl acrylate and an acrylate containing a pentaalkyldisiloxane group. A method for preparing beaded polyethylene glycol-based resins in silicone oil in the presence of a polymeric surfactant containing a pentaalkyldisiloxane group is also described. The average bead size can be controlled by varying the stirring rate, the polymerization temperature, the amount of surfactant, the type of solvent, and the amount of solvent. The surfactant does not interfere with the polymerization and can be removed together with residual silicone oil by a simple washing procedure. The resins can be used, for example, as a support for solid phase organic synthesis, as a chromatographic resin, as a resin for solid phase MAS-NMR spectroscopy, and as a carrier for drug molecules, various reagents, or scavengers. C08G65/332; C08L71/02; C08G65/00; C08L71/00; (IPC1-7): C08F220/28; A61K9/16; A61K47/48; C08F230/08; C08G61/06; C08J3/09. European:C08G65/332D; C08L71/02. 333. M. Meldal and T. E. Nielsen. Heterocyclic organic molecules through intramolecular formation of n-acyliminium ions. Carlsberg A/S. Anonymous. US20040561803 20040625; PCT/DK2004/000454(US2006252093; WO2004113362 (A3)WO2004113362 (A2)EP1648921 (A3)EP1648921 (A2)EP1648921 (A0)), 2006. Abstract of US2006252093 The present invention relates to a method of preparing heterocyclic organic com-pounds involving intramolecular formation of an N-acyliminium ion and an in-tramolecular Pictet-Spengler reaction. The invention furthermore discloses precursor molecules useful for the method and methods of preparing these precursor mole-cules. The invention also relates to heterocyclic organic compounds prepared by the methods, libraries of such heterocyclic organic compound and methods of preparing them, as well as to various uses of the heterocyclic organic compounds. C40B40/04; C07D265/06; C07D413/12; C07D471/04; C07D471/14; C07D495/14; C07K1/04; C40B40/10; C40B40/04; C07D265/00; C07D413/00; C07D471/00; C07D495/00; C07K1/00. European:C07D265/06; C07D413/12; C07D471/04; C07D471/14; C07D495/14; C07K1/04C. 334. M. Meldal, J. Buchardt, and J. Rademann. PEG-based macromonomers, Chemically inert polymers prepared therefrom and the use of these polymers for organic synthesis and enzyme reactions. Carlsberg A/S. Anonymous. Denmark:DK19990945955T 19990928; US20010787881 20010628; PCT/DK99/00580(US7064179; WO0018823 (A3) WO0018823 (A2) EP1137690 (A3) EP1137690 (A2) EP1137690 (A0) CA2345332 (A1) EP1137690 (B2) EP1137690 (B1) ES2232176T (T3) DE69921850T (T2) CZ296517 (B6) AU766181B (B2); DK1137690T):1-34, 2006. Abstract of US7064179 The present invention relates to macromonomers containing ethylene glycol repeat units, to chemically inert polymers prepared therefrom and to the use of such polymers in solid phase biochemical assays. A macromonomer of polyethylene glycol having repeat units in the range 6-300 and having at least one end terminated by an ether group having formula (I) where m is an integer of 0-10, a is an integer of 1-4, and R is H or alkyl or aryl or arylalkyl; or having formula (II) where m is an integer of 1-10, and R is H or alkyl or aryl or arylalkyl. 09-28-1998. C07D305/00; G01N37/00; A61B1/247; B01D15/08; B01J20/26; B01J20/281; B01J20/30; C07C231/12; C07C237/12; C07D305/06; C07K1/04; C07K17/08; C08F2/00; C08F2/32; C08F283/06; C08F290/06; C08F299/02; C08G65/22; C08G65/26; C08G65/32; C08G65/329; C08G65/331; C08G65/34; C12N11/08; G01N30/88; G01N37/00; A61B1/24; B01D15/08; B01J20/22; B01J20/281; B01J20/30; C07C231/00; C07C237/00; C07D305/00; C07K1/00; C07K17/00; C08F2/00; C08F2/32; C08F283/00; C08F290/00; C08F299/00; C08G65/00; C12N11/00; G01N30/00. Patent. European:A61B1/247B; C08F283/06; C08F290/06; C08F290/06B; C08G65/22. Gamle Carlsberg Vej 10, DK-2500 Valby, Denmark. 335. M. Meldal, T. E. Nielsen, G. Hagel, D. W. Kaznelson, F. Diness, and O. Thastrup. Identification of compounds modifying a cellular response. Carlsberg A/S. Anonymous. Denmark:EP20050744506 20050525; PCT/DK2005/000348(EP1761783; WO2005116656 (A1)WO2005116643 (A3)WO2005116643 (A2)EP1761783 (A3)EP1759212 (A1)), 2007. WO2005116656: The present invention relates to methods for identifying compounds capable of modulating a cellular response. The methods involve attaching living cells to solid supports comprising a library of test compounds. The test compounds are linked to the solid support via cleavable linkers and may thus be released from the solid supports. Solid supports comprising cells, wherein the cellular response of interest has been modulated are selected and the test compound of the solid support can then be identified. The cellular response may for example be changes in complex formation between proteins. G01N33/68; C07K1/04; C07K5/00; C07K5/103; C07K7/00; C07K7/06; C07K7/08; G01N33/50; G01N33/543; G01N35/00; G01N33/68; C07K1/00; C07K5/00; C07K7/00; G01N33/50; G01N33/543; G01N35/00. European:C07K1/04C; C07K5/10A1A; C07K7/06A; C07K7/06B; C07K7/08A; C07K7/08B; G01N33/50D2E2; G01N33/543D; G01N33/68A10. 336. R. Michael, I. Johannsen, and M. Meldal. High capacity poly(alkylene)glycol based amino polymers. VERSAMATRIX A/S. Anonymous. Denmark:US4745134; WO03031489; WO0018823; GB1558491; WO9901469. WO2004DK00461 20040628(WO2004113389):filed, 2003. Abstract of WO2004113389: The present invention relates to a cross-linked and beaded, stable and high loading capacity polymer matrix for affinity chromatography applications and for solid phase synthesis. The polymer matrix can be obtained by a method comprising the steps of providing a plurality of macromonomers each comprising a poly(oxalkylene) chain terminated with an acylamide functional group, polymerising said macromonomers using a free radical initiator or an ionic initiator, optionally with the addition of copolymerizing agents, and converting in the beaded polymer matrix at least 50% of the amide groups to amine functional groups by reduction of the amide groups with a suitable reducing agent. C08F8/30; C08G65/322; C08G65/333; C08L71/02; C08F8/00; C08G65/00; C08L71/00; (IPC1-7): C07K17/00. European:C08F8/30; C08G65/322; C08G65/333F2; C08L71/02. 337. R. Michael and M. Meldal. Polyethyleneimine polymers. Anonymous. Anonymous. WO0056792 US3134740 WO9639156 WO02085381 US3766299 WO03085031 XP000978327 XP009034930. WO2004DK00330 20040510(WO2004099288):filed 10-5 2003, 2004. Abstract of WO2004099288: The present invention relates to the development of a beaded high loading capacity polymer for solid phase synthesis and purification of solution-phase organic synthesis. The matrix comprises cross-linked polyethyleneimine units as in the formula (I), where is a real number of 5-1500, and designates the average degree of polymerisation (dp) of polyethyleneimine, ã and õ are real numbers ranging from O to . The high density primary and secondary amino functional groups on the resin function as the site for the excess reagents to react. In a particular aspect there is provided a cross-linked polymer matrix selected from the group consisting of a cross-linked polymer matrix formed from a macromonomer comprising a polyethyleneimine functionalized with at least one fragment comprising a vinyl group, wherein said fragment can be polymerized using radical or ionic initiators to form the cross-linked polymer matrix, or a cross-linked and beaded polymer matrix formed from a macromonomer comprising a polyethyleneimine and a polyfunctional alkyllating agent, under inverse suspension or inverse emulsion polymerisation conditions. C08F290/06; C08G73/02; C08F290/00; C08G73/00; (IPC1-7): C08G73/02; A61K31/785; C08F290/06. European:C08F290/06; C08F290/06D; C08G73/02A9; C08G73/02E. 338. L. P. Miranda and M. Meldal. One dimensional unichemo protection (UCP) in organic synthesis. Carlsberg A/S. Anonymous. USA:AU20020309138 20020409(AU2002309138; WO02081413 (A3); WO02081413 (A2); US2002146684 (A1)):1-35, 2002. US2002146684: A protected template molecule and a new one-dimensional UniChemo Protection (UCP) organic synthetic method for preparing polyfunctional organic molecules is described. The synthetic method can be used with many kinds of chemical reactions and provides selective access to many functional groups in a template molecule. The method utilizes protection groups that are each composed of building block units that can be removed one by one affording a new protection group one unit shorter or exposing a functional group on the template molecule. The exposed functional group on the template molecule can react with a target group. Different target groups can be introduced into the template molecule by using protection groups containing different numbers of building block units. C03C17/30; C03C17/34; C07B61/00; C07K1/04; C07K14/00; G01N33/543; A61K38/00; A61K39/00; C03C17/28; C03C17/34; C07B61/00; C07K1/00; C07K14/00; G01N33/543; A61K38/00; A61K39/00; (IPC1-7): C12N1/00; C07H21/00; C07K1/00; C12Q1/68; G01N33/552. European:C03C17/30; C03C17/34B; C07B61/00L; C07K1/04A; C07K1/04C; C07K14/00B; G01N33/543; G01N33/543F. 339. L. P. Miranda and M. Meldal. Matrix for solid-phase organic synthesis. Carlsberg A/S. Anonymous. Denmark:US20020270245 20021015; EP20020800549 20021011(US2003144467; EP1448644; WO03031489 (A3); WO03031489 (A2); EP1448644 (A0); CA2501165 (A1)):1-54, 2003. Abstract of US2003144467 The present invention relates to a polymer matrix comprising a backbone of linked macromonomers, wherein said macromonomers are selected from the group consisting of triethylene glycols, tetraethylene glycols, and pentaethylene glycols, including any derivative and/or combination thereof. The polymer matrix of the present invention has a high-loading capacity while still being able to swell in small volumes of organic and aqueous solvents; it forms beads effectively so as to provide a resin of homogeneous size and shape; and it is more stable both chemically and physically than state of the art resins. One preferred type of SPOCC resin according to the present invention comprises short chained ethylene glycol macromonomers, including tetraethylene glycol (TEG194), or derivatives thereof. C08F283/06; C08F290/06; C08F290/14; C08G65/18; C08G65/22; C08L51/08; C08F283/00; C08F290/00; C08G65/00; C08L51/00; C08G65/34; (IPC1-7). European:C08F283/06; C08F290/00; C08F290/06; C08F290/06B; C08F290/14; C08F290/14B; C08G65/18; C08G65/22; C08L51/08. 340. N. Rao, M. Meldal, K. Bock, and O. Hindsgaul. Library of glyco-peptides useful for identification of cell adhesion inhibitors. Glycomed Corporation. Anonymous. California/USA:US19960664303 19960610(US5795958; WO9510296 (A1) WO 94US11370):1-28, 1998. Abstract of US5795958: Glycopeptides having the following structure are described: wherein: X1 is hydrogen, an acetyl group, an acyl group or amino acid; R is alpha -L-fucose, alpha -D-fucose, beta -L-fucose or beta -D-fucose, wherein R is O-glucosidically linked to A1; A1 is serine, threonine, tyrosine, hydroxyproline, asparagine, glutamine, homeoserine and hydroxylysine; A2 is a glycine, an L-amino acid, a D-amino acid or a modified amino acid; A3 is L or D aspartic acid, glycine or glutamic acid; and X2 is a hydroxyl, an amine or an amino acid. Glycopeptides having the following structure are described: wherein: X1 is hydrogen, an acetyl group, an acyl group or amino acid; R is alpha -L-fucose, alpha -D-fucose, beta -L-fucose or beta -D-fucose, wherein R is O-glucosidically linked to A1; A1 is serine, threonine, tyrosine, hydroxyproline, asparagine, glutamine, homeoserine and hydroxylysine; A2 is a glycine, an L-amino acid, a D-amino acid or a modified amino acid; A3 is L or D aspartic acid, glycine or glutamic acid; and X2 is a hydroxyl, an amine or an amino acid. G01N33/53; A61K38/00; A61K38/22; A61P5/00; A61P31/04; A61P35/00; C07K1/04; C07K9/00; C07K16/18; G01N33/53; A61K38/00; A61K38/22; A61P5/00; A61P31/00; A61P35/00; C07K1/00; C07K9/00; C07K16/18; (IPC1-7): A61K38/06. European:C07K1/04C; C07K9/00D. 341. R. Sheppard and M. Meldal. Monitoring method for the synthesis of a linear of amino acid residues. MEDICAL RES COUNCIL. Anonymous. GB19860002586 19860203(GB2187461; WO8704713 (A3)WO8704713 (A2)EP0257053 (A3)EP0257053 (A2)US5126273 (A1)), 1980. Abstract of corresponding document: WO8704713 Monitoring method which finds particular (but not exclusive) application in solid phase peptide synthesis. In one aspect, the synthesis starts with an amino acid residue protected by an N-alpha-amino protecting group and involves the steps: (a) removing the N-alpha-amino protecting group to obtain an N-alpha-amino group, (b) adding an amino acid residue protected by an N-alpha-amino protecting group, via a peptide bond, to the N-alpha-amino group obtained in step (a) by use of a reactive protected amino acid derivative and, where necessary, a catalyst, and (c) repeating steps (a) and (b) until the desired linear combination has been obtained; the reaction system includes 3-hydroxy-1,2,3-benzotriazin-4(3H)-one or a derivative thereof; and the colour of the reaction system or of a component thereof is monitored during the synthesis. The solvent is preferably a polar aprotic solvent, e.g. dimethylformamide. Where the synthesis is a solid phase synthesis, the solid phase is preferably a polyamide. Apparatus for carrying out these methods is also disclosed. In a preferred embodiment, this apparatus comprises (i) a column for receiving particles including a polyamide resin on which the solid phase synthesis is to take place; (ii) a light source disposed on one side of said column; (iii) a focussing arrangement disposed adjacent said column and opposite said light source; (iv) a photometer positioned to receive light focussed by said focussing arrangement; and (v) a microprocessor programmed to respond to the output of said photodetector and to control the synthesis procedure in response thereto. G01N33/68; C07K1/02; C07K1/04; C07K1/06; C07K1/08; G01N33/68; C07K1/00; (IPC1-7): C07K1/00. European:C07K1/02; C07K1/04; C07K1/08. Filed unpublished patents, 342. C. W. Tornøe and M. Meldal. Use of peptide-substituted triazoles as protease inhibitors. Combio A/S. PA 2002 00845; US60/385,231(abandoned):1-74, 2003. 05-31-2002. 343. M. Meldal and M. Renil. Macromonomers and polymers therefrom. Ltd. Polymer Laboratories. England: UK 9609911.4(abandoned):1-23, 1996.